Palonosetron and aprepitant for prevention of postoperative nausea and vomiting in patient undergoing laparoscopic gynecology surgery.
Phase 4
Completed
- Conditions
- postoperative nausea and vomiting in patients undergoing laparoscopic gynecologic surgeryAnaesthesiology - Anaesthetics
- Registration Number
- ACTRN12613000902796
- Lead Sponsor
- Chung-ang university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 100
Inclusion Criteria
patients undergoing laparoscopic gynecologic surgery
Exclusion Criteria
Pregnant women, 60 years of age or older and under 20 years old, weight 45kg or less, or more than 100kg, more than American society of Anesthesiologist grade three , history of previous postoperative nausea and vomiting, history of motion sickness, smokers, patient of serious cardiovascular system, kidney, liver, and hematological abnormalities.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method severity of nausea assessed using 100 point-visual analogue scale(VAS)[at time of waking from anaesthesia 0hr, 2hr, 6hr, 24hr, 48hr];incidence of vomiting[at time of waking from anaesthesia 0hr, 2hr, 6hr, 24hr, 48hr];rescue antiemetics recorded by nurse[at time of waking from anaesthesia0hr, 2hr, 6hr, 24hr, 48hr]
- Secondary Outcome Measures
Name Time Method pain score assessed using 100 point-visual analogue scale[at time of waking from anaesthesia 0hr, 2hr, 6hr, 24hr, 48hr];fentanyl consumption recorded by nurse[at time of waking from anaesthesia 0hr, 2hr, 6hr, 24hr, 48hr];rescue analgeics recorded by nurse[at time of waking from anaesthesia 0hr, 2hr, 6hr, 24hr, 48hr]