ACTRN12609000440224
Withdrawn
Phase 3
A multi-centre, randomised clinical trial examining the effect of Clopidogrel versus Aspirin in addition to optimal medical therapy for heart failure on subsequent heart failure hospitalisation and mortality in patients with class III-IV congestive heart failure.
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversity of Sydney
- Enrollment
- 1250
- Status
- Withdrawn
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Men or women age \>18 years
- •2\. Symptomatic heart failure
- •3\. Serum N\-terminal pro\-B\-type natriuretic peptide (NT\-proBNP) of \>600pg/mL
- •OR NT\-proBNP \>400pg/mLa \+ Heart Failure (HF) hospitalisation within last 12 months
- •4\. Treatment with an angiotensin converting enzyme (ACE) inhibitor (unless not tolerated) and ongoing treatment with a diuretic
- •5\. Provision of written informed consent
Exclusion Criteria
- •1\. Contraindication to aspirin or clopidogrel
- •2\. Indication for chronic anti\-coagulation
- •3\. Heart failure due to a reversible cause or hypertrophic or infiltrative cardiomyopathy
- •4\. Unstable heart failure or treatment regimen
- •5\. Life\-limiting systemic illness
- •6\. Severe chronic obstructive pulmonary disease (COPD) (as evidenced by history of mechanical ventilation, need for home oxygen, or treatment with oral corticosteroids) for more than 3 continuous days within 12 months
- •7\. Conditions that might interfere with protocol compliance
Outcomes
Primary Outcomes
Not specified
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