GO-ACTIWE Energy Metabolism

Not Applicable

Completed

• Conditions: Overweight and Obesity
• Interventions: Behavioral: Physical activity

• Registration Number: NCT01973686
• Lead Sponsor: University of Copenhagen

Brief Summary

The aim of the present study is to investigate the changes in body composition and the degree of compensation to exercise induced energy expenditure after 1 year of physical activity with either moderate or vigorous intensity in overweight and class 1 obese men and women. The present study is a sub study to main study "Active Commuting To Improve Well-being and Health in Everyday Life" (NCT 01962259)

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-10-21
• Study First Submitted QC: 2013-10-25
• Study First Posted: 2013-10-31
• Study Start: 2013-11
• Primary Completion: 2016-06
• Study Completion: 2017-07
• Status Verified: 2018-07
• Last Update Submitted: 2018-07-31
• Last Update Posted: 2018-08-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 188

Inclusion Criteria

• Participation in main study (NCT 01962259)

Exclusion Criteria

• No participation in main study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Vigorous intensity LTPA	Physical activity	Leisure time physical activity (LTPA): Exercise intensity: 70% of maximal oxygen uptake (VO2 max); Energy expenditure: Females: 1600 kcal/week; Males: 2100 kcal/week
Moderate intensity LTPA	Physical activity	Leisure time physical activity (LTPA): Exercise intensity: 50% VO2 max; Energy expenditure: Females: 1600 kcal/week; Males: 2100 kcal/week

Primary Outcome Measures

Name	Time	Method
Total body fat	Change from baseline in body fat at 6 months	Changes in total body fat (kg) measured by dual x-ray absorptiometry

Secondary Outcome Measures

Name	Time	Method
Appetite control	Baseline, 3 and 6 months	Appetite control determined via 1. blood samples (peptides and metabolites) and 2. self rated sensations (visual analogue scales) in relation with standardized meals and exercise, as well as 3. ad libitum energy intake and 4. Eating behaviours determined via three-factor eating questionaire
Net energy balance and degree of compensation	3 and 6 months	1. Net energy balance calculated from changes in body composition, and 2. the degree of compensation as the difference between energy spent during exercise and net energy balance
Anthropometry	Baseline, 3 and 6 months	Body composition measured by dual x-ray absorptiometry, height, weight, waist and hip circumference, sagittal abdominal height
Compensatory mechanisms	Baseline, 3 and 6 months	1. Resting metabolic rate determined by indirect calorimetry, 2. Total physical activity (TPA) measured using accelerometry, 3. Non-exercise activity determined as the difference between TPA and exercise activity, and 4. Energy intake determined by food records and during meal tests

Trial Locations

Locations (1)

University of Copenhagen, Department of Biomedical Sciences; 🇩🇰 Copenhagen, Denmark