Lysophosphatidylglycerol in Asthma Pathogenesis

Recruiting

• Conditions: Asthma

• Registration Number: NCT06327516
• Lead Sponsor: Peking University Third Hospital

Brief Summary

The study aims to investigate the relationship between the small molecule metabolite lysophosphatidylglycerol and asthma clinical features and explore its involvement in asthma pathogenesis.

Detailed Description

This study screened LPG as a asthma marker by performing metabolomics of the included asthma patients and normal controls, explored the relationship between LPG and clinical features of asthma (including acute exacerbation, asthma control state, asthma treatment steps，lung function, and inflammatory signals including eosinophils, FeNO and total IgE), and further performed in vitro tests to investigate the specific mechanism of LPG's involvement in asthma inflammation through its influence on Treg function.

Study Timeline

• Study Start: 2015-01-01
• Status Verified: 2024-03
• Study First Submitted: 2024-03-17
• Study First Submitted QC: 2024-03-17
• Last Update Submitted: 2024-03-24
• Study First Posted: 2024-03-25
• Last Update Posted: 2024-03-26
• Primary Completion: 2024-12-31
• Study Completion: 2025-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

1. clinical diagnosis of asthma.

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Exclusion Criteria

1. Combined with chronic obstructive pulmonary disease, bronchiectasis, pneumonia, obstructive sleep apnea hypopnea syndrome, malignant tumor
2. Combined with acute and chronic respiratory failure
3. Combined with severe cardiovascular disease
4. Pregnant woman.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
lipidomics	when enrolled	collect blood for lipidomic analysis and in vitro assays on Day1

Trial Locations

Locations (1)

Peking university third hospital; 🇨🇳 Beijing, None Selected, China