Demonstration of Carbonyl Stress on Hair Follicles
- Conditions
- Effluvium; Telogen
- Interventions
- Other: Hair follicles sampling
- Registration Number
- NCT03414476
- Lead Sponsor
- Pierre Fabre Dermo Cosmetique
- Brief Summary
In this study, the investigator will try to highlight the presence of carbonyl compounds in the hair follicles of women with telogen effluvium (ET) linked to stress of various origins (fatigue, infectious diseases, emotional stress ...).
- Detailed Description
At the cutaneous level, oxidative stress induces the formation of carbonyl compounds which, by binding to proteins, produce nonfunctional adducts inducing cutaneous aging. Is this mechanism, called "Carbonyl stress", also present in the scalp and can it be one of the mechanisms involved in the occurrence of reactive hair loss ? To demonstrate this, samples of hair follicles are made. The proteins are extracted from the samples and then assayed. The oxidized (carbonyl) proteins are labeled with specific fluorescent probes.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 40
Criteria related to the Population :
- Women aged from 18 to 40 ans (included)
- Phototype I à IV included, according to Fitzpatrick Classification
- Hair length 5 cm on the sampling area (centro-parietal part)
- Last shampoo at least 2 days before the inclusion visit, without application of styling product, care or water between this last shampoo and the inclusion
- Informed consent signature
Criteria related to the studied condition:
- ET group: hair loss related to various etiologies evaluated by a questionnaire according to the investigator's opinion and positive pull test (at least 3 hair collected per lock of 50 to 60 hair) AND
- Control group : no hair loss, evaluated by the questionnaire and negative pull test (less than 3 hair collected per lock of 50 to 60 hair)
Criteria related to Population :
- Menopause
- Pregnancy, breastfeeding, childbirth for less than 6 months
Criteria related to Pathology :
For both groups:
- Alopecia causing hair loss on the upper part of the scalp
- Dermatological pathology or evolving cutaneous lesion in the scalp
- Control group only:
- Chronic unstabilized condition
- Acute evolving pathology
Criteria related to theTreatments :
For both groups:
- Use for at least 1 month of Minoxidil, Aminexil in the 3 months before inclusion or ongoing
- Systemic treatment affecting hair growth
- Any treatment or dietary supplement for antioxidant or capillary
Control group only:
- Treatment of general thyroid disorders initiated or modified for less than 3 months prior to inclusion
- Treatment of anemia if started less than 3 months before inclusion
- General treatment initiated or modified for less than 3 months prior to inclusion in the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description ET group Hair follicles sampling Sampling : Hair follicles sampling on the scalp in women with Telogene Effluvium Control group Hair follicles sampling Sampling: Hair follicles sampling on the scalp in women without Telogene Effluvium
- Primary Outcome Measures
Name Time Method Biological evaluation Visit 1- Day 1 Evaluation of the quantity of carbonyl compounds measured in the hair follicles taken from the two groups.
- Secondary Outcome Measures
Name Time Method Safety evaluation Visit 1- Day 1 Adverse events evaluation
Trial Locations
- Locations (6)
Centre de Pharmacologie Clinique Appliquée à la Dermatologie
🇫🇷Nice, France
Centre hospitalier Lyon Sud
🇫🇷Lyon, France
Centre de santé SABOURAUD
🇫🇷Paris, France
INTERTEK France
🇫🇷Paris, France
Centre de Recherche sur la Peau
🇫🇷Toulouse, France
Laboratoire Dermscan
🇫🇷Villeurbanne, France