Analysis of genetic information and single nucleotide polymorphisms(SNPs) in Korean periodontitis patients with genome-wide association study(GWAS)

Seoul National University Dental Hospital0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年7月23日

适应症

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•? Among patients who have visited Seoul National Dental Hospital, subjects who are in need of oral examinations.
•? Adult male and female patients between the ages of 19-75, have healthy or periodontally compromised teeth.

•? Subjects who fall under periodontitis grade B, when the tooth with most severe bone loss is used to calculate the value of % bone loss/age.
•? Subjects who have taken antibiotics within the past 3 months.
•? Subjects who have taken immunosuppressants (methotrexate, leflunomide, tacrolimus, cyclosporin, azathioprine) or corticosteroids (oral or IV injection) within the past 3 months.
•? Subjects with uncontrolled hypertension of diabetes.
•? Subjects with severe conditions relating to, or concomitant cardiovascular disease, respiratory disease, kidney disease, liver disease, blood system disease and neuropsychiatric disease.
•? Subjects with hyperthyroidism or hypothyroidism.
•? Pregnant women.
•? Subjects with autoimmune diseases.
•? Subjects with an ongoing disease or history of malignant tumors in the jaw bone.
•? Patients with ongoing issues or history of alcohol or drug abuse within 1 year.
•? Subjects with oral ulcers, Herpes simplex or Herpes zoster, fungal or bacterial infections, or any other inflammatory conditions affecting the oral mucosa unrelated to periodontitis.
•? Other cases in which the subjects’ participation may be considered inappropriate due to ethical reasons or may compromise the results of research.

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