Genome-wide association study of periodontitis in the Korean populatio

Not Applicable

Completed

• Conditions: Diseases of the digestive system

• Registration Number: KCT0008436
• Lead Sponsor: Seoul National University Dental Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2024-06-25
• Last Update Posted: 23 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

? Among patients who have visited Seoul National Dental Hospital, subjects who are in need of oral examinations.
? Adult male and female patients between the ages of 19-75, have healthy or periodontally compromised teeth.

Exclusion Criteria

? Subjects who fall under periodontitis grade B, when the tooth with most severe bone loss is used to calculate the value of % bone loss/age.
? Subjects who have taken antibiotics within the past 3 months.
? Subjects who have taken immunosuppressants (methotrexate, leflunomide, tacrolimus, cyclosporin, azathioprine) or corticosteroids (oral or IV injection) within the past 3 months.
? Subjects with uncontrolled hypertension of diabetes.
? Subjects with severe conditions relating to, or concomitant cardiovascular disease, respiratory disease, kidney disease, liver disease, blood system disease and neuropsychiatric disease.
? Subjects with hyperthyroidism or hypothyroidism.
? Pregnant women.
? Subjects with autoimmune diseases.
? Subjects with an ongoing disease or history of malignant tumors in the jaw bone.
? Patients with ongoing issues or history of alcohol or drug abuse within 1 year.
? Subjects with oral ulcers, Herpes simplex or Herpes zoster, fungal or bacterial infections, or any other inflammatory conditions affecting the oral mucosa unrelated to periodontitis.
? Other cases in which the subjects’ participation may be considered inappropriate due to ethical reasons or may compromise the results of research.

Study & Design

• Study Type: Observational Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
genome-wide information

Secondary Outcome Measures

Name	Time	Method
Probing pocket depth, gingival recession, clinical attachment level, gingival index, plaque index), tooth loss, bleeding on probing, tooth mobility, furcation involvement, Alveolar bone loss at the mesial and distal