Multicenter retrospective study of clinical, endoscopic and pathological characteristics of autoimmune gastritis
Not Applicable
- Conditions
- Autoimmune gastritis
- Registration Number
- JPRN-UMIN000033785
- Lead Sponsor
- Kakogawa Central City Hospital, Department of Gastroenterology
- Brief Summary
Repeated incorrect treatments for H. pylori infection due to a false-positive result in 13C-urea breath test, ranked third among the basis for diagnosis of AIG. Associated gastric lesions were type 1 neuroendocrine tumor (11.4%), adenocarcinoma (9.8%). Corpus pan-atrophy was the most common appearance. Remnant oxyntic mucosa was found in 31.5% of the patients. Sticky adherent dense mucus and scattered minute whitish protrusions were observed in approximately 30% of the patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 245
Inclusion Criteria
Not provided
Exclusion Criteria
The patients who were prescribed proton pomp inhibitor or vonoprazan fumarate and the patients who underwent gastrectomy or had renal failure.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) Endoscopic findings: Kyoto gastritis classification and other findings like remnant oxyntic mucosa, status of antrum, mucous condition. Findings through indigo carmine dying method or NBI magnifying method. 2) Histological findings of each biopsy site, number of biopsies. 3) Blood sample results: titer of anti-parietal cell antibody, existence of anti-intrinsic factor antibody, PG1, PG 2, PG 1/2, RBC, Hb, Ht, MCV, WBC, platelet, VB12, folic acid, Fe, TSH, anti-thyroglobulin antibody, anti-glutamic acid decarboxylase antibody, blood sugar, HbA1C and others presumed to be related AIG. 4) Helicobacter pylori infection associated data :13C-UBT, anti H. pylori IgG antibody and H. pylori stool antigen. 5) Other associated clinical information, if available.
- Secondary Outcome Measures
Name Time Method