Effect of Plasma Rich in Growth Factors (PRGF) on Semen Quality
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Evaluate the percentage of motile sperm adding PRGF versus those samples that growth factors were not added
研究概览
简要总结
The hypothesis is growing semen samples with plasma rich in growth factors (PRGF), because it could improve sperm motility in patients subsidiary TRA, ultimately improving pregnancy rates.
详细描述
Platelet growth factors are a group of proteins involved in cellular communication modifying biological responses. Obtaining plasma rich in growth factors is already widespread and simple protocol technique that is being used in various areas of medicine with superb results. Described many of the growth factors present in the PRGF are related to sperm parameters, especially motility The described effects have been studied in mammalian and each growth factor individually. PRGF contains a pool of growth factors and therefore be interesting to analyze their effect on various sperm parameters.
One of those parameters is very important for fertilization sperm motility, since the lack of it will prevent displacement by the cervix to meet the egg in the fallopian tube.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18-35 years
- •more than 5 million sperm per milliliter
排除标准
- •Not having genetic and infectious diseases
- •Do not suffer mental illness
- •Have a family study determined that there is no risk of hereditary diseases
- •There have fathered more than 6 children in the country
结局指标
主要结局
Evaluate the percentage of motile sperm adding PRGF versus those samples that growth factors were not added
时间窗: 6 months
Within concerted donor visits in IVI Bilbao will be held: * Removing Blood 9 mL of blood to obtain plasma rich in factors growth * Seminogram to analyze all semen parameters according to the criteria of the WHO (2010), paying particular attention to sperm motility. * Sperm vitality will be analyzed before and after treatment with PRGF. PRGF application on the seminal aliquots will be conducted at different concentrations assessing sperm motility.
次要结局
未报告次要终点