Relationship Between Pressure and Flow Velocity on Coronary Physiology
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Sponsor
- Hyogo Medical University
- Locations
- 1
- Primary Endpoint
- Wave intensity
Study Overview
Brief Summary
Subjects are patients who are planned to do percutaneous coronary intervention for coronary stenosis in the left circumflex artery without other stenosis in the left ascending artery and the right coronary artery, or a patient with normal coronary artery. Immediately after coronary angiography or percutaneous coronary intervention, the investigators will evaluate for coronary hemodynamics by distribution of wave intensity which is calcurated by coronary pressure and flow velocity with Combowire in each coronary segment. Also, they will assess coronary morphology by View It in each coronary segment.
Detailed Description
Combowire (Volcano Therapeutics Inc., CA, USA) is a 0.014 inch pressure/Doppler sensor-tipped-guidewire which can measure coronary pressure and flow velocity.
View It (Terumo Co., Japan) is a guide catheter with intravascular ultrasound which can measure coronary morphology such as vessel diamter.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •A patient who are planned to do percutaneous coronary intervention for stenosis in the left circumflex artery without any lesions in other coronary arteries
- •Or a patient who is performed coronary angiography without significant stenosis lesion in 3-coronary vessel
Exclusion Criteria
- •A patient with coronary stenosis with LAD
- •Hemodialysis
- •Acute coronary syndrome
- •Congestive heart failure
- •A patient with shock vitals
Arms & Interventions
Normal coronary artery
Intervention: combowire and IVUS (Device)
Outcomes
Primary Outcomes
Wave intensity
Time Frame: Immediately after coronary angiography or percutaneous coronary intervention
Secondary Outcomes
- Vessel diameter(Immediately after coronary angiography or percutaneous coronary intervention)
- Coronary pressure(Immediately after coronary angiography or percutaneous coronary intervention)
- Flow velocity(Immediately after coronary angiography or percutaneous coronary intervention)
Investigators
Kenichi Fujii
Relationship between pressure and flow velocity on coronary physiology
Hyogo Medical University