Interaction Between Right Heart Dysfunction and Emphysema: Impact of Endoscopic Lung Volume Reduction (RVDD)
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Estimate the change in right diastolic cardiac function after reduction of emphysema
研究概览
简要总结
Heart-lung interactions remain misunderstood whereas pulmonary and cardiac pathologies are very commonly associated.
Emphysema by increasing intrathoracic pressure appears to affect cardiac function.
Interestingly, previous studies have shown a link between the telediastolic volume of the right ventricle (measured by RMI) and the intensity of emphysema.
Our hypothesis is that the emphysema by increasing intrathoracic pressure leads to or accentuates right cardiac diastolic dysfunction by decreasing compliance and cardiac preload.
To verify this hypothesis the investigators will perform KT loop procedures in order to acquire intracardiac pressure/volume curves before and after lung volume reduction.
The pressure/volume curves allow the analysis of systolic and diastolic function, cardiac contractility and loading conditions.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Estimate the change in right diastolic cardiac function after reduction of emphysema
时间窗: 1 day
Estimate the change in right diastolic cardiac function after reduction of emphysema : assessed by the change in the slope end diastolic pressure volume relationship (EDPVR mmHg/ml) obtained by KT Loop procedure
次要结局
- Evaluate the evolution of symptoms assessed(1 day)
- Evaluate the evolution of respiratory function(1 day)
- Estimate the change in right systolic heart function(1 day)
- Estimate the change in right cardiac contractility(1 day)
- Estimate ventriculo-arterial coupling(1 day)
- Assessing exercice performance(1 day)