Impact of Nebivolol on Central Aortic Pressure

Not Applicable

Withdrawn

• Conditions: Central Aortic Pressure
• Interventions: Drug: Nebivolol; Drug: Metoprolol

• Registration Number: NCT01051947
• Lead Sponsor: Creighton University

Brief Summary

A randomized, cross-over, single-blind study to compare the effects of nebivolol and metoprolol on central aortic pressure and peripheral brachial pressure in patients with stable cardiovascular disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-12
• Study First Submitted: 2010-01-19
• Study First Submitted QC: 2010-01-19
• Study First Posted: 2010-01-20
• Primary Completion: 2010-05
• Study Completion: 2010-05
• Status Verified: 2011-07
• Last Update Submitted: 2011-07-29
• Last Update Posted: 2011-08-01

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Subjects with history of hypertension
• Subjects who have received metoprolol for a minimum of 3 months

Exclusion Criteria

• Patients who have had an acute myocardial infarction, coronary revascularization or who have been hospitalized for heart failure or cardiac arrhythmia in the past 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Nebivolol	Nebivolol	Nebivolol therapy for 2-6 weeks depending on blood pressure readings
Metoprolol	Metoprolol	Metoprolol therapy for 2-6 weeks depending on blood pressure readings

Primary Outcome Measures

Name	Time	Method
Stable blood pressure	6 months	Subjects will be randomized to nebivolol or metoprolol. Their medication will be titrated so that their blood pressure is within 10% of their initial reading.

Trial Locations

Locations (1)

The Cardiac Center at Creighton University; 🇺🇸 Omaha, Nebraska, United States