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Clinical Trials/NCT01705288
NCT01705288
Completed
Early Phase 1

Implementation of a Rapid Recovery Program in Gynecologic Oncology Surgery: A Pilot Study

Masonic Cancer Center, University of Minnesota1 site in 1 country103 target enrollmentStarted: January 1, 2013Last updated:

Overview

Phase
Early Phase 1
Status
Completed
Enrollment
103
Locations
1
Primary Endpoint
Hospital Stay

Overview

Brief Summary

Over 600,000 hysterectomies are performed annually in the United States. Despite increasing use of less invasive approaches, the majority of hysterectomies are still performed via traditional laparotomy, which can be associated with generally slower recovery and longer lengths of post-operative hospitalization. Rapid Recovery Protocols (RRP) seek to optimize post-surgical morbidity outcomes by returning a patient to normal physiology as quickly as possible following surgery.

Detailed Description

Subjects will be randomly assigned to one of two groups: Rapid recovery protocol (regional anesthesia, pain control options with emphasis on nonsteroidal anti-inflammatory drugs (NSAIDS) over narcotic pain medications, early ambulation, and early enteral feeding) or standard of care (traditional laparatomy and supportive care).

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Supportive Care
Masking
None

Eligibility Criteria

Ages
19 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Women who are being seen at the Women's Health Center by the Gynecologic Oncology group at the University of Minnesota if planned surgery includes an exploratory laparotomy

Exclusion Criteria

  • \< 19 years old
  • Undergoing a procedure other than laparotomy
  • Scheduled to be discharged the same day of surgery
  • Chronic narcotic pain medication user
  • American Society of Anesthesiologists (ASA) score of \> or = 3
  • Any condition that would exclude women from undergoing regional anesthesia

Arms & Interventions

Control Group (Standard Laparotomy)

Active Comparator

Patients undergoing standard anesthesia and standard exploratory laparotomy. Treatment will be per your surgeon's routine standards.

Intervention: Laparotomy (Procedure)

Control Group (Standard Laparotomy)

Active Comparator

Patients undergoing standard anesthesia and standard exploratory laparotomy. Treatment will be per your surgeon's routine standards.

Intervention: intravenous narcotics (Drug)

Control Group (Standard Laparotomy)

Active Comparator

Patients undergoing standard anesthesia and standard exploratory laparotomy. Treatment will be per your surgeon's routine standards.

Intervention: standard anesthesia (Drug)

Rapid Recovery Group

Experimental

Protocol for "rapid recovery laparotomy" procedure involves pre-operative counseling, the use of regional anesthesia (spinal or epidural pain management rather than intravenous narcotics), post-operative use of non-steroidal anti-inflammatory drugs, early eating after surgery, early walking, and certain goals for discharge from the hospital.

Intervention: Laparotomy (Procedure)

Rapid Recovery Group

Experimental

Protocol for "rapid recovery laparotomy" procedure involves pre-operative counseling, the use of regional anesthesia (spinal or epidural pain management rather than intravenous narcotics), post-operative use of non-steroidal anti-inflammatory drugs, early eating after surgery, early walking, and certain goals for discharge from the hospital.

Intervention: regional anesthesia (Drug)

Rapid Recovery Group

Experimental

Protocol for "rapid recovery laparotomy" procedure involves pre-operative counseling, the use of regional anesthesia (spinal or epidural pain management rather than intravenous narcotics), post-operative use of non-steroidal anti-inflammatory drugs, early eating after surgery, early walking, and certain goals for discharge from the hospital.

Intervention: Non-steroidal anti-inflammatory drugs (Drug)

Outcomes

Primary Outcomes

Hospital Stay

Time Frame: 1 Month

Length of hospital stay for patients undergoing laparotomy on the gynecologic oncology service measured as whole days from the day of surgery until discharge

Secondary Outcomes

  • Pain Medications Used(Post operative - day 2)
  • Pain Assessment(Day 0)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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