High Intensity Interval Training and Hypoxic Conditioning in Obese Patients

Not Applicable

• Conditions: Obesity
• Interventions: Other: Constant load exercise training N; Other: High intensity interval training H; Other: Hypoxic conditioning at rest; Other: Normoxic conditioning at rest; Other: High intensity interval training N; Other: Constant load exercise training H

• Registration Number: NCT02642705
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

The present study aims at evaluating the effect of two innovative treatment strategies in obese patients: high intensity interval training and hypoxic conditioning. Obese patients will be randomized in groups performing high intensity interval training, constant load training, hypoxic conditioning or placebo normoxic conditioning for 8 weeks. The effects of the interventions will be measured regarding exercise tolerance, blood pressure, body composition, metabolic status.

Detailed Description

120 obese patients will be randomized to 6 intervention groups. Each group will follow an 8-week intervention (3 session per week) with either high intensity interval training in normoxia or hypoxia, constant load exercise training in normoxia or hypoxia, hypoxic or normoxic (placebo) conditioning at rest. Exercise capacity, metabolic status, blood pressure, vascular function and physical activity will be assessed before and after the intervention.

Study Timeline

• Study Start: 2015-09
• Study First Submitted: 2015-12-24
• Study First Submitted QC: 2015-12-24
• Study First Posted: 2015-12-30
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-17
• Last Update Posted: 2020-03-18
• Primary Completion: 2021-04
• Study Completion: 2021-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• BMI between 27 and 35 kg/m²
• Physical activity <2 hours/week
• No chronic disease or treatment able to interfere with inflammation and metabolic perturbatiosn associated with obesity

Exclusion Criteria

• Diabetes mellitus treated with insulin
• Auto-immune or inflammatory diseases requiring long term therapy
• Unstable dysthyroidism
• Bariatric surgery within the past 18 months
• Tumoral, inflammatory, infectious, cardiac, respiratory, kidney, digestive disease
• Untreated sleep apnea

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Constant load exercise training N	Constant load exercise training N	Constant load exercise training N: The intervention consists in 8-week exercise training, 3 times a week for one hour, according to a constant load training protocol (50% maximal power output), breathing ambient air (normoxia)
High intensity interval training H	High intensity interval training H	High intensity interval training H: The intervention consists in 8-week exercise training, 3 times a week for one hour, according to a high intensity interval training protocol (1 min ON at 100% maximal power output, 1 min OFF), breathing hypoxic air (about 3 500 m of altitude)
Hypoxic conditioning at rest	Hypoxic conditioning at rest	Hypoxic conditioning at rest : The intervention consists in 8-week conditioning period, 3 times a week, hypoxic breathing for one hour (about 4500 m of altitude) while seating quietly
Normoxic conditioning at rest	Normoxic conditioning at rest	Normoxic conditioning at rest : The intervention consists in 8-week conditioning period, 3 times a week, normoxic breathing for one hour (ambient air) while seating quietly
High intensity interval training N	High intensity interval training N	High intensity interval training N: The intervention consists in 8-week exercise training, 3 times a week for one hour, according to a high intensity interval training protocol (1 min ON at 100% maximal power output, 1 min OFF), breathing ambient air (normoxia)
Constant load exercise training H	Constant load exercise training H	Constant load exercise training H: The intervention consists in 8-week exercise training, 3 times a week for one hour, according to a constant load training protocol (50% maximal power output), breathing hypoxic air (about 3 500 m of altitude)

Primary Outcome Measures

Name	Time	Method
Maximal exercise capacity	8 weeks	Maximal oxygen consumption during an incremental exercise test

Secondary Outcome Measures

Name	Time	Method
Blood pressure	8 weeks	24 h ambulatory blood pressure mesurement
Vascular function	8 weeks	Post-ischemic hyperemia (Endo-Pat) and pulse wave velocity
Body composition	8 weeks	MRI fat free mass and adipose tissue measurements
Metabolic status	8 weeks	Blood lipids, glycemia, HOMA index, oxydative stress and inflammatory status
Physical activity	8 weeks	Spontaneous physical activity measured by accelerometry

Trial Locations

Locations (1)

Grenoble University Hospital; 🇫🇷 Grenoble, Rhone Alpes, France