Influence of Cardio-ventilatory Factors on Exercise Intolerance in Obese Adolescents: Effects of Exercise Training

Not Applicable

Completed

• Conditions: Obesity
• Interventions: Behavioral: Exercise training

• Registration Number: NCT01411605
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Worldwide, childhood and adolescent obesity has reached epidemic proportions despite major efforts to promote weight reduction. Pediatric obesity commonly presages adult obesity and is associated with the development of weight-related comorbid conditions and increased morbidity.

Regular physical activity is an important modality of obesity management. Despite controversies, poor exercise tolerance has frequently been reported in youth obesity and the cause of this limited exercise tolerance remains unknown. Several factors accompanying obesity may interfere with exercise tolerance in obese populations. Respiratory factors, such as decreased thoracic compliance, increased airway resistance and breathing at low pulmonary volumes are associated with obesity and may impact exercise intolerance in this population. Moreover, even in people with otherwise normal lungs, the normal ventilatory responses to exercise can become constrained in obesity. A thorough understanding of the mechanisms underlying this exercise intolerance remains fundamental in order to favour long term adherence to exercise training. This is especially true in youth populations, in which the management of overweight and obesity must be undertaken as soon as possible, due to the early onset of cardiovascular risk factors.

The main purpose of this study is to determine early-onset cardio-respiratory mortality factors in obese adolescents as well as their relation with exercise intolerance (i.e. dyspnea) when compared with age and gender-paired normal-weight volunteers.

Detailed Description

Physiopathological trial. Expected total enrollment : 20 obese adolescents + 20 control subjects Tested treatment: Exercise training (4 hours per week). Treatment duration: 12 weeks

Study Timeline

• Study Start: 2007-09
• Study First Submitted: 2011-07-29
• Study First Submitted QC: 2011-08-04
• Study First Posted: 2011-08-08
• Primary Completion: 2012-03
• Study Completion: 2012-03
• Status Verified: 2012-06
• Last Update Submitted: 2012-06-26
• Last Update Posted: 2012-06-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Male and female obese adolescents (BMI > IOTF 30, 12-16 years old)

Exclusion Criteria

• Cardiovascular pathology
• Pathology interfering with physical activity (neurological pathology, severe respiratory illness i.e. asthma, renal failure)
• Diabetes (known or treated)
• Participation in another study
• Asthma (known and treated)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Exercise training	Exercise training	12-week supervised exercise-training (ET) program consisting of two 60-min and one 120-min exercise sessions per week which focus mainly on aerobic exercises (cycling, treadmill, rower). Initial aerobic exercise intensity is set at 60 % of HR peak and will reach 80 % at the end of the ET protocol.

Primary Outcome Measures

Name	Time	Method
Exercise tolerance (Expiratory flow limitation and Operational Lung Volumes at rest and exercise, cardiorespiratory and subjective responses to incremental exercise)	Participants will be followed for the duration of exercise training, an expected average of 12 weeks

Secondary Outcome Measures

Name	Time	Method
Polysomnography	Participants will be followed for the duration of exercise training, an expected average of 12 weeks	Explore the potential existence of obstructive sleep apnea and its effects on cardiovascular adaptations during exercise.
Cardiorespiratory fitness (VO2max)	Participants will be followed for the duration of exercise training, an expected average of 12 weeks

Trial Locations

Locations (1)

CHU Grenoble; 🇫🇷 Grenoble, France