KCT0000757招募中未知
Effects of Ticagrelor and intracoronary morphine on Myocardial Salvage in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 20(Year) 至 o Limit（—）
- 性别
- All
入选标准
- •1.General inclusion criteria
- •-Subject must be at least 20 years of age.
- •-Patients undergoing primary PCI for STEMI
- •-Diagnosis of STEMI: ST-segment elevation >0.1 millivolt in =2 contiguous leads or (presumably) new left bundle branch block
- •-Presence of symptoms less than 12 hours
- •2.Additional inclusion criteria for intracoronary morphine
- •-TIMI flow grade 0 or 1 of infarct related arteries
排除标准
- •3.Exclusion Criteria:
- •- Known hypersensitivity or contraindication to study medications or contrast
- •- Female of childbearing potential, unless a recent pregnancy test is negative, who possibly plan to become pregnant any time after enrollment into this study.
- •- Rescue PCI after thrombolysis or facilitated PCI
- •- Cardiogenic shock or cardiopulmonary resuscitation before randomizatio
- •- Known chronic hepatic disease
- •- Known renal dysfunction (creatinine level 3.0mg/dL or dependence on dialysis).
- •- Decompensated chronic obstructive pulmonary disease or active asthma at inclusion
- •- Mechanical ventilation at inclusion
- •- Brain injury or intracranial hypertension
- •- Acute alcohol intoxication
- •- Known ulcerative colitis
- •- Active epilepsy
- •- Contraindications to undergo MRI imaging include any of the following
- •: A cardiac pacemaker or implantable defibrillator; any implanted or magnetically activated device; or any history indicating contraindication to MRI including claustrophobia or allergy to gadolinium
- •- Current use of oral anticoagulant
- •- An increased risk of bradycardia
- •:Sinus node dysfunction, atrioventricular dysfunction, or heart rate <40/min
- •- Patients receiving clopidogrel 300 mg or more before randomization
- •- One of followings
- •:1)history of intracranial bleeding
- •2)intracranial tumor, arteriovenous malformation or aneurysm
- •3)stroke within past 3 months
- •- Active bleeding of internal organ or bleeding diathesis
- •- Acute aortic dissection
研究者
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