A randomized clinical study of encapsulated kale extract for pain reduction and anti-inflammatory effect after surgical removal of impacted mandibular third molar
Phase 1
Completed
- Conditions
- pain in patients after surgical removal of impacted mandibular third molarpain, mandibular third molar, pro-inflammatory cytokines, alpha-amylase, kale
- Registration Number
- TCTR20231028001
- Lead Sponsor
- Residency Training Program in Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Healthy based on the criteria of American Society of Anesthesiologists (ASA) Level I and II, Following surgical removal of impacted mandibular third molar (mesioangulation)
Exclusion Criteria
Allergic to ibuprofen, inflammation after surgical removal of impacted mandibular third molar, take analgesic drug 1 week prior to surgery, psychological disorders, no communication nor co-operation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method pain four days after surgical removal of impacted mandibular third molar VAS meter,salivary alpha-amylase activity 4 days after surgical removal of impacted mandibular third molar colorimetry,salivary transforming growth factor beta four days after surgical removal of impacted mandibular third molar ELISA
- Secondary Outcome Measures
Name Time Method salivary matrix metalloproteinase 9 4 days ELISA