The Use of Rhythmic Light Therapy in Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- EEG-based neural synchrony
研究概览
简要总结
In this within-subjects, crossover study, participants will undergo Electroencephalogram (EEG) recordings before, during, and after each of three 1-hour sessions. All participants will experience all three conditions: (1) dual-frequency visual (10 and 40 Hz), (2) single-frequency visual (40 Hz), and (3) non-rhythmic stimulation. EEG spectral power and amplitude coupling will be analyzed to determine whether stimulation-induced increases in alpha-gamma neural synchrony translate to improvements in cognitive performance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 55 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •History of Mild Cognitive Impairment with a Montreal Cognitive Assessment score between 18 and 25
排除标准
- •History of epilepsy or photosensitivity
- •Blindness or other obstructive vision conditions
- •retinal diseases
- •presence of another brain disease accounting for their cognitive status
研究组 & 干预措施
Dual frequency flickering light
Light flickering with 10 Hz + 40 Hz visual stimulation
干预措施: Flickering Light (Device)
Single frequency flickering light
Light flickering with 10 Hz visual stimulation
干预措施: Flickering Light (Device)
non-rhythmic flickering light
Light flickering with random visual stimulation
干预措施: Flickering Light (Device)
结局指标
主要结局
EEG-based neural synchrony
时间窗: 5 minute EEG recording will be done at start, middle and end of each one-hour session, each session separated by one week
Change in spectral power and amplitude in the alpha and gamma EEG bands. Increase in power and amplitude is indicative of increases in neural synchrony.
次要结局
- Digit Span Task(Completed at start and end of each one-hour session, each session will be separated by one week)
研究者
Mariana Figueiro
Professor
Icahn School of Medicine at Mount Sinai