Age of Blood evalution.

• Conditions: Complications occuring after red cell transfusion in ICU patients

• Registration Number: NL-OMON25580
• Lead Sponsor: Sanquin Blood bankRegion South-WestPO-box 21842301 CD LeidenThe Netherlands

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 2000

Inclusion Criteria

We will include patients who:

1. Have had a request for a first red cell unit transfusion in the ICU (or in the emergency department after admission to the ICU was requested by an intensivist), and;

Exclusion Criteria

1. Less than 18 years of age;

2. For whom there is verbal or written report of a red cell transfusion during the current hospitalisation (including time in emergency room and/or during transport in ambulance and/or time in another hospital prior to the transfer, whatever the length of the first hospitalization is);

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In the ABLE-NL study the primary analysis will be on nosocomial infections, especially pneumonia. Pneumonia is the only clinical endpoint that has been reported more than once to remain statistically significantly correlated with storage time, even after adequate correction for total number of RBC transfusions. Increases in pneumonia of up to 6% for each additional day of storage have been reported.

Secondary Outcome Measures

Name	Time	Method
As compared to standard issue red cells, we will ascertain whether red cells stored 7 days or less:<br /><br>1. Decrease in-hospital, ICU, 28-day, 90-day and 6-month mortality;<br /><br>2. Decrease the severity of multiple organ dysfunction syndrome (MODS), as measured by the number of organ dysfunction and MODS score;<br /><br>3. Decrease serious nosocomial infections;<br /><br>4. Reduce the length of ICU and hospital stays;<br /><br>5. The occurence of alloimmunisation after transfuion of red cells.<br /><br>Special attention will also be paid to red cell transfusions and transfusion reactions.