The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pain
- Sponsor
- Xianwei Zhang
- Enrollment
- 1533
- Locations
- 1
- Primary Endpoint
- Preoperative Pressure Pain Threshold (PPT)
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population. Methods: Patients receiving elective surgery under general anesthesia were recruited into this study. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). Pain intensity at rest and movement after the operation was evaluated . And the PCA drug consumption were recorded. Also there were healthy college students volunteer be recruited into this study. The investigators measured their experimental pain sensitivity including pressure pain threshold (PPT) and pressure pain tolerance (PTO), etc. Then genotyping was carried out.
Detailed Description
Subjects with the following diseases were excluded: known history of chronic disease, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, Pregnancy or at lactation period .
Investigators
Xianwei Zhang
Clinical Professor
Huazhong University of Science and Technology
Eligibility Criteria
Inclusion Criteria
- ••Aged 18-65 years
- •Receiving elective gynecological laparoscopic surgery
- •Anesthesiologists (ASA) physical status I or II
- •Agreed to participate the research
Exclusion Criteria
- ••History of chronic pain
- •Psychiatric diseases
- •Diabetes mellitus
- •Severe cardiovascular diseases
- •Kidney or liver diseases
- •Alcohol or drug abuse
- •Heavy smoker
- •Pregnancy or at lactation period
- •Disagree to participate to the research
Outcomes
Primary Outcomes
Preoperative Pressure Pain Threshold (PPT)
Time Frame: 30 minutes before the operation
The probe of pressure algometer was positioned perpendicularly to the skin surface of the patient, and the investigator applied continuous pressure at approximately the same rate according to the visual LCD display on the algometer. subjects were asked to say "pain" when they started to feel pain during the stimulation. The value from the LCD was recorded as the pressure pain threshold.
Secondary Outcomes
- Preoperative Pressure Pain Tolerance (PTO)(30 minutes before the operation)