The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,533
- 试验地点
- 1
- 主要终点
- Preoperative Pressure Pain Threshold (PPT)
研究概览
简要总结
Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population. Methods: Patients receiving elective surgery under general anesthesia were recruited into this study. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). Pain intensity at rest and movement after the operation was evaluated . And the PCA drug consumption were recorded. Also there were healthy college students volunteer be recruited into this study. The investigators measured their experimental pain sensitivity including pressure pain threshold (PPT) and pressure pain tolerance (PTO), etc. Then genotyping was carried out.
详细描述
Subjects with the following diseases were excluded: known history of chronic disease, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, Pregnancy or at lactation period .
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- ••Aged 18-65 years
- •Receiving elective gynecological laparoscopic surgery
- •Anesthesiologists (ASA) physical status I or II
- •Agreed to participate the research
排除标准
- ••History of chronic pain
- •Psychiatric diseases
- •Diabetes mellitus
- •Severe cardiovascular diseases
- •Kidney or liver diseases
- •Alcohol or drug abuse
- •Heavy smoker
- •Pregnancy or at lactation period
- •Disagree to participate to the research
结局指标
主要结局
Preoperative Pressure Pain Threshold (PPT)
时间窗: 30 minutes before the operation
The probe of pressure algometer was positioned perpendicularly to the skin surface of the patient, and the investigator applied continuous pressure at approximately the same rate according to the visual LCD display on the algometer. subjects were asked to say "pain" when they started to feel pain during the stimulation. The value from the LCD was recorded as the pressure pain threshold.
次要结局
- Preoperative Pressure Pain Tolerance (PTO)(30 minutes before the operation)
研究者
Xianwei Zhang
Clinical Professor
Huazhong University of Science and Technology