Dental Management of Patients Living With HIV: A Retrospective Study Using COREVIH Data in Pays de la Loire
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 5,603
- 试验地点
- 1
- 主要终点
- Proportion of Patients Requiring Adapted Dental Management
研究概览
简要总结
Dental care for people living with HIV has evolved with the widespread use of antiretroviral therapy, which has improved life expectancy and disease control. However, uncertainty remains about whether specific adaptations are still needed during dental procedures due to potential biological abnormalities that may increase infectious or bleeding risks.
This study aims to evaluate the proportion of patients living with HIV in the Pays de la Loire region who may require adapted dental management based on biological parameters such as immune status, hematological values, and comorbidities.
A retrospective descriptive study will be conducted using anonymized data from 5,603 patients followed in the COREVIH Pays de la Loire database. The results are expected to provide objective data to better inform dental practice and reduce unnecessary precautions or stigmatization in the management of patients living with HIV.
详细描述
This is a retrospective descriptive observational study using anonymized data from patients living with HIV followed in the Pays de la Loire region. The dataset includes 5,603 individuals whose data were previously collected as part of routine clinical care and recorded in the Nadis medical database by healthcare professionals involved in HIV management.
Data were provided by the COREVIH Pays de la Loire in an anonymized format and include demographic characteristics (age, sex), HIV-related variables (viral load, duration since diagnosis, antiretroviral therapy status), co-infections (sexually transmitted infections and hepatitis B/C), biological parameters (CD4 lymphocyte count, neutrophil count, platelet count, hemoglobin level), and comorbidities (e.g., diabetes, hypertension, renal disease, cardiovascular conditions, depression).
The primary objective is to determine the proportion of patients presenting biological abnormalities that may increase the risk of infectious or hemorrhagic complications during invasive dental procedures.
Data analysis will consist of descriptive statistics, including frequencies and percentages for categorical variables. The study does not involve any intervention, additional data collection, or direct patient contact.
All data are fully anonymized prior to analysis, ensuring that participants cannot be identified. The study complies with applicable data protection regulations and is based on previously collected clinical data.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients aged ≥18 years
- •Confirmed diagnosis of HIV infection
- •Followed at participating hospital centers
- •Available clinical and biological data relevant to dental care management (CD4 count, viral load, blood count)
排除标准
- •Patients with missing key biological data required for analysis
- •Patients not followed in participating centers
- •Patients with incomplete medical records preventing assessment of outcomes
研究组 & 干预措施
Patients With HIV
Patients living with HIV included in a retrospective cohort using anonymized data from the COREVIH Pays de la Loire database. The study population includes adults followed in routine clinical care, with available demographic, clinical, biological, and comorbidity data used to assess factors relevant to dental management.
干预措施: HIV infection status and clinical characteristics (Other)
结局指标
主要结局
Proportion of Patients Requiring Adapted Dental Management
时间窗: At time of data extraction (retrospective baseline)
Percentage of patients living with HIV presenting at least one biological abnormality associated with increased risk of infectious or hemorrhagic complications during invasive dental procedures, including low CD4 count, neutropenia, thrombocytopenia, or anemia, based on routinely collected clinical data.
次要结局
- CD4 Cell Count Distribution(At time of data extraction (retrospective baseline))
- Neutrophil Count Distribution(At time of data extraction (retrospective baseline))
- Platelet Count Distribution(At time of data extraction (retrospective baseline))
- Hemoglobin Level Distribution(At time of data extraction (retrospective baseline))
- Prevalence of Comorbidities(At time of data extraction (retrospective baseline))
- Viral Load Status(At time of data extraction (retrospective baseline))