Association Between Viscoelastic Tests-Guided Therapy With Synthetic Factor Concentrates And Allogenic Blood Transfusion In Liver Transplantation: A Before-After Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 237
- 主要终点
- Need of Any Blood Products Transfusion
研究概览
简要总结
BACKGROUND: Perioperative bleeding and transfusion are important causes of morbidity and mortality in patients undergoing liver transplantation. The aim of this study is to assess whether viscoelastic tests-guided therapy with the use of synthetic factor concentrates impact transfusion rates of hemocomponents in adult patients undergoing liver transplantation.
METHODS: This is an interventional before-after comparative study. Patients undergoing liver transplantation before the implementation of a protocol using thromboelastometry and synthetic factor concentrates were compared to patients after the implementation. Primary outcome was transfusion of any hemocomponents. Secondary outcomes included: transfusion of red blood cells (RBC), fresh frozen plasma (FFP), cryoprecipitate or platelets, clinical complications, length of stay and in-hospital mortality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Deceased Donor Liver Transplantation
- •Chronic Liver Disease
排除标准
- •Acute Liver Failure
- •Combined Transplantation
- •Re-Transplantation is Less Than 30 Days After the First Transplant
研究组 & 干预措施
Usual Care (Before)
No Thromboelastometry No Synthetic Factor Concentrates Usual Care
干预措施: Usual Care (Other)
Thromboelastometry-Guided Therapy (After)
Thromboelastometry-Guided Therapy with Synthetic Factor Concentrates
干预措施: Thromboelastometry-Guided Therapy with Synthetic Factor Concentrates (Other)
结局指标
主要结局
Need of Any Blood Products Transfusion
时间窗: 48 Hours
Collapsed composite of need of any transfusion of blood product during surgery and in the first 48 hours in the postoperative, including the need of RBC, FFP, cryoprecipitate and/or platelets.
次要结局
- Duration of Mechanical Ventilation(Third days or until hospital discharge, whichever occurs first)
- ICU Length of Stay(Third days or until ICU discharge, whichever occurs first)
- Hospital Length of Stay(Third days or until hospital discharge, whichever occurs first)
- Use of Synthetic Factor Concentrates or Antifibrinolytic(48 Hours)
- Clinical Complications Related to the Procedure(Third days or until hospital discharge, whichever occurs first)
- In-Hospital Mortality(Third days or until hospital discharge, whichever occurs first)