Supporting Decisions With Transcranial Direct Current Stimulation in Healthy Young and Elderly Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 254
- 试验地点
- 1
- 主要终点
- Influence of Stimulation on the Decisions
研究概览
简要总结
Decisions are part of the daily life. On the neuronal level, activity in the dorsolateral prefrontal cortex (dlPFC) is important during complex decisions (e.g., whether something is emotional for a person or not). We apply transcranial direct current stimulation (tDCS) with the aim to increase dlPFC activity and thereby modulate decisions towards emotional content.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
Double blind design
入排标准
- 年龄范围
- 20 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Written informed consent
- •Non-smokers
- •Right-handedness
- •Native German speakers or comparable level of fluency
- •Normal or corrected-to-normal vision
排除标准
- •Neurological or psychiatric condition (other than diagnosed cognitive impairment)
- •Past head injuries
- •Magnetizable implants
- •History of seizures
- •Current or life-time alcohol or drug abuse
- •Skin diseases
- •tES in the 3 months preceding or during the present study
- •Caffeine 3 hours prior to training
研究组 & 干预措施
Real tDCS
20 min of 1 mA real anodal transcranial direct current stimulation applied via 5x7 cm rubber electrodes over the DLPFC (current density: 0.028 mA/cm2). Additional ramp-up and ramp-down phase at beginning and end of stimulation lasting for 15 s. Electrodes remain attached to the participant's head for the duration of the decision task.
干预措施: real anodal transcranial direct current stimulation (Device)
Sham tDCS
30 s of 1 mA anodal tDCS applied via 5x7 cm rubber electrodes over the DLPFC (current density: 0.028 mA/cm2). Additional ramp-up and ramp-down phase at beginning and end of stimulation lasting for 15 s. Electrodes remain attached to the participant's head for the duration of the decision task.
干预措施: sham transcranial direct current stimulation (Device)
结局指标
主要结局
Influence of Stimulation on the Decisions
时间窗: 10 minutes
Number of words which were rated as positive or negative.
次要结局
- Profile of Mood States (POMS; after stimulation)(3 minutes)
- Positive and Negative Affect Schedule (PANAS; before stimulation)(2 minutes)
- Positive and Negative Affect Schedule (PANAS; after stimulation)(2 minutes)
- Profile of Mood States (POMS; before stimulation)(3 minutes)