MLPR As A Diagnostic Marker For Acute Pulmonary Embolism

Completed

• Conditions: Pulmonary Embolism (Diagnosis); Diagnosis

• Registration Number: NCT07023705
• Lead Sponsor: Ain Shams University

Brief Summary

A retrospective study to assess the utility of hematological marker (monocyte to large platelet ratio) to diagnose patients with pulmonary embolism

Detailed Description

The investigators conducted a retrospective review of emergency department records of patients who presented with signs and symptoms suggestive of pulmonary embolism (PE) and underwent CT pulmonary angiography (CTPA) for diagnosis. Hematological laboratory findings obtained prior to any treatment were collected and compared between two groups based on CTPA results: those with confirmed PE (CT positive) and those without PE (CT negative).

Study Timeline

• Study Start: 2024-01-01
• Primary Completion: 2024-12-31
• Study Completion: 2025-05-31
• Status Verified: 2025-06
• Study First Submitted: 2025-06-09
• Study First Submitted QC: 2025-06-09
• Last Update Submitted: 2025-06-16
• Study First Posted: 2025-06-17
• Last Update Posted: 2025-06-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Only patients with the results of full blood count and white blood cell differentiation, measured before the treatment of suspected PE.
• Patients underwent CT pulmonary angiography to confirm or exclude pulmonary embolism diagnosis.

Exclusion Criteria

• Patient with history of any myeloproliferative disorder, myelofibrosis, Glanzmann thrombasthenia, May-Hegglin anomaly, Bernard-Soulier syndrome, suspicion of disseminated intravascular coagulation.
• Patient receiving any anticoagulant drug at a therapeutic dose.
• Patient with blood transfusion in the last 2 months.
• Patients with acute coronary syndrome, pulmonary edema.
• Patient on immunosuppressive drugs , Oral contraceptive pills .
• Patients with severe renal or hepatic disease.
• Patients with Stroke.
• Patients with malignancy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Monocyte-to-Large Platelet Ratio (MLPR)	At emergency department admission (baseline lab measurement) before any treatment.	A ratio between monocyte absolute count and the large platelets count (MLPR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by area under the curve (AUC) , sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).

Secondary Outcome Measures

Name	Time	Method
Mean platelet volume (MPV)	At emergency department admission (baseline lab measurement) before any treatment.	MPV values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV.
Neutrophil to Lymphocyte Ratio (NLR)	At emergency department admission (baseline lab measurement) before any treatment.	The ratio between absolute neutrophil and absolute lymphocytes count (NLR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV.
D-Dimer Levels	At emergency department admission (baseline lab measurement) before any treatment.	D-Dimer concentration values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV.
Platelet Distribution Width (PDW)	At emergency department admission (baseline lab measurement) before any treatment.	PDW values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV.
Platelet To Lymphocyte Ratio (PLR)	At emergency department admission (baseline lab measurement) before any treatment.	The ratio between total platelets count and absolute lymphocytes count (PLR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV.

Trial Locations

Locations (1)

Ain Shams University; 🇪🇬 Cairo, Egypt