Are Anxiety and Depression Associated Psychological Traits in Severe asthma?

The University of Newcastle0 个研究点目标入组 50 人开始时间: 2020年2月4日最近更新: 2021年7月5日

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•o18 years of age or older
•oConfirmed diagnosis of severe asthma
•oSevere asthma is defined according to International European Respiratory Society and American Thoracic Society Guidelines as asthma requiring high-dose inhaled corticosteroids with a second controller to prevent uncontrolled” disease or disease that remains uncontrolled” despite therapy.
•oPrescribed high-dose inhaled corticosteroids (above 1000µg beclomethasone equivalent) PLUS a second controller (may include long-acting beta agonists; and/or long-acting muscarinic antagonists, and/or maintenance oral corticosteroids for 50% of the past year; and/or montelukast; and/or theophylline).
•oRequires a monoclonal antibody (mAb) therapy to control asthma or remains uncontrolled despite a mAb.
•oHave uncontrolled asthma determined by:
•oscores on the Asthma Control Questionnaire that equal a score of 1.5 or above;
•oand/or frequent severe exacerbations (where 2 courses of administered systemic corticosteroids are evident for 3 or more days each in the previous year);
•oand/or a serious exacerbation in the previous year (hospitalisation, intensive care unit stay, mechanical ventilation);
•oand/or persistent airflow limitation (pre-bronchodilator FEV1 of less than 80% predicted in the face of a reduced FEV1/FVC of less than 0.7).

•oAged less than 18 years
•oNon-English speaking
•oCognitive impairment including a diagnosis of dementia and delirium
•oDiagnosed acute psychosis that includes symptoms of hallucinations and delusions
•oInability to attend study visits
•oNot willing or able to provide consent

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