Prospective Cohort for Finding Risk Factors of Meconium Obstruction and Respiratory Distress Syndrome in Preterm Infants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Comparison of citrulline level between the meconium obstruction group and the normal feeding advance group
研究概览
简要总结
Although the pathophysiology of meconium obstruction of prematurity (MOP) is not clear, it is known that the decrease of the intestinal peristalsis due to decreased intestinal perfusion during antenatal or perinatal period. Recently, the level of citrulline has been used as an index of function and injury of the small intestine State. This study aimed to evaluate citrulline level of cord blood as a marker for early detection and observe changes in intestinal blood flow in MOP patient.
And We aimed to confirm the efficacy of the AT/ET ratio (ratio of the pulmonary artery time-to-peak velocity interval to the right ventricular ejection time) of the prenatal pulmonary artery as a noninvasive predictor of neonatal respiratory distress syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 34 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •premature infants born less than 34 weeks from mother with pregnancy induced hypertension, pre-eclampsia or eclampsia
排除标准
- •major congenital anomalies
- •infants with hypotension while using inotropics
结局指标
主要结局
Comparison of citrulline level between the meconium obstruction group and the normal feeding advance group
时间窗: within 6 hours after birth
check the citrulline llevel from blood at birth
Comparison of prenatal AT/ET ratio of fetal pulmonary artery between respiratory distress syndrome group and the normal respiration group
时间窗: within 10 days before delivery
Check the AT/ET ratio of fetal pulmonary artery within 10 days before birth
次要结局
未报告次要终点
研究者
Ee-Kyung Kim
Professor
Seoul National University Hospital