intra-individual platelet activation, as meased by PFA-200, at different time lapses after aspirin intake
Completed
- Conditions
- Acute thrombo-embolische aandoeningen (cq. myocardinfarct, herseninfarct)Acute thromboembolic events10064477
- Registration Number
- NL-OMON39536
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Outpatients from the cardiology and vascular surgery departments. Intake of respectively 100 mg or 80 mg of carbasalate calcium or acetylsalicylic acid once a day.
Exclusion Criteria
* active bleeding
* thrombocytopenia
* thrombocytosis
* recent use of antiplatet drugs, anticoagulants or drugs that are known to alter platelelet function, other than aspirin (e.g. NSAID*s, tirofiban, eptifibatide, abciximab, beta-lactam antibiotics, dextran, SSRI*s, clomipramine & amitriptyline, dipyridamole, verapamil, diltiazem , ginkgo biloba, ginseng, St John*s wort)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>platelet activability as measured by PFA-200</p><br>
- Secondary Outcome Measures
Name Time Method <p>platelet count<br /><br>platelet activability as measured by chronolog<br /><br>hemoglobone</p><br>