Elucidating the therapeutic mechanism of DBS by simultaneously stimulating and recording from the target brain region.

Completed

Conditions: Obsessive-compulsive disorder
anxiety disorder
10037173

Registration Number: NL-OMON50295

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 11

Inclusion Criteria

Subject has provided informed consent.
Primary diagnosis of OCD with DBS-implantation performed in the AMC in the
previous years.
Primary diagnosis of OCD and indicated for DBS-implantation in the AMC.
DBS-treatment responsiveness, defined as an improvement in Y-BOCS of >35% at
last follow-up compared to pre-surgical baseline

Exclusion Criteria

Subject is unwilling or unable to comply with all study-required follow-up
evaluations.
Alcohol or substance abuse during last 6 months

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. DBS-related changes in amplitude, phase stability and frontostriatal<br /><br>connectivity of theta (~4 Hz), alpha (~10 Hz) and gamma (>40 Hz) EEG<br /><br>oscillations at electrode contacts and scalp<br /><br>2. Amplitude, phase stability of theta, alpha and gamma EEG oscillations<br /><br>measured at the electrodes that prelude and accompany the emergence of a<br /><br>compulsive episode during real-life situations<br /><br>3. DBS-related clinical changes on clinician-rated questionnaires:<br /><br>- Yale Brown of Obsessive-Compulsive Scale (Goodman et al., 1989)<br /><br>- Hamilton Scale for Depression (Hamilton, 1960)<br /><br>- Hamilton Anxiety Scale (Hamilton, 1959)<br /><br>- Symptom provocation during IAPS picture task (Bradley and Lang, 2007)<br /><br>- Shortened 5-item obsessive-compulsive scale (VAS - visual analogue scale)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Characteristics of corticostriatal EEG oscillations that are associated with<br /><br>various cognitive and behavioral paradigms and with sleep.<br /><br>2. Written dairy of OCD symptom experiences and daily activities (for 1 day)<br /><br>3. Demographic information not obtainable from clinical file (e.g. handedness)</p><br>