Effect of Intranasal Administration of Orexine A on IL-6-System, Sleep-Wake-Regulation and Neurocognition
Not Applicable
- Conditions
- Narcolepsy
- Registration Number
- NCT00484757
- Lead Sponsor
- Zentrum für Integrative Psychiatrie
- Brief Summary
15 patients with narcolepsy and 15 healthy controls will be included in the study. According to a randomized, double-blind protocol they will receive intranasally at night first Orexine A and approximately two weeks later placebo or vice versa. Thereafter sleep will be recorded, the cytokine-system and neurocognition characterized.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Narcolepsy
- Age >18
- Informed consent
- GERMAN fluently spoken
Exclusion Criteria
- Additional severe psychiatric or somatic disorders
- Pregnancy or nursing
- Anemia (Hb<10g/dl)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Effect of orexine A on sleep, neurocognition and immune-system
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Zentrum für Integrative Psychiatrie
🇩🇪Kiel, Germany
Zentrum für Integrative Psychiatrie🇩🇪Kiel, Germany