Evaluation of nebulised Dexmedetomidine to attenuate hemodynamic response to laryngoscopy and endotracheal intubation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- To evaluate the efficacy of nebulised Dexmedetomidine given pre- operatively to attenuate Hemodynamic response to laryngoscopy and Endotracheal intubation.
研究概览
简要总结
Dexmedetomidine in various doses and routes has been studied such as intravenous, intranasal, intramuscular to decrease the hemodynamic response to laryngoscopy and Endotracheal intubation.
However,intravenous administration may cause bradycardia and hypotension and intranasal administration may be associated with irritation.
This studt is about how Nebulised Dexmedetomidine may offer an alternative to both intravenous as well as intranasal routes of administration,since the drug deposition following nebulization takes place over nasal, buccal as well as respiratory mucosa. The nasal mucosa accounts for 65% of the bioavailability of nebulised Dexmedetomidine,while buccal mucosa accounts for 82%.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients of ASA grade I and ASA grade II Age group
- •60 years MPG I and II BMI less than 35.
排除标准
- •Patient refusal Patients requiring more than 15 seconds for intubation or more than 1 attempts of Laryngoscopy Patients taking medicines that affect the heart rate such as clonidine,beta –blockers Patients undergoing emergency surgeries will be excluded from the study.
结局指标
主要结局
To evaluate the efficacy of nebulised Dexmedetomidine given pre- operatively to attenuate Hemodynamic response to laryngoscopy and Endotracheal intubation.
时间窗: Before laryngoscopy,After laryngoscopy,1 min,5 min,10 min After intubation
次要结局
- To calculate total amount of Propofol used during induction of General Anesthesia & Fentanyl during surgery(For Propfol at baseline & for Fentanyl after 1 hr to end of surgery)