This study looks at using a medication called dexmedetomidine in a nebulizer to help the patient to relax and reduce heart rate and blood pressure changes during laryngoscopy and intubation
- Conditions
- Healthy human volunteers posted for elective surgeries belong to ASA grade I AND II
- Registration Number
- CTRI/2025/04/085416
- Lead Sponsor
- Gandhi medical college
- Brief Summary
Dexmedetomidine in various doses and routes has been studied such as intravenous, intranasal, intramuscular to decrease the hemodynamic response to laryngoscopy and Endotracheal intubation.
However,intravenous administration may cause bradycardia and hypotension and intranasal administration may be associated with irritation.
This studt is about how Nebulised Dexmedetomidine may offer an alternative to both intravenous as well as intranasal routes of administration,since the drug deposition following nebulization takes place over nasal, buccal as well as respiratory mucosa. The nasal mucosa accounts for 65% of the bioavailability of nebulised Dexmedetomidine,while buccal mucosa accounts for 82%.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 96
- Patients of ASA grade I and ASA grade II Age group 20.
- 60 years MPG I and II BMI less than 35.
Patient refusal Patients requiring more than 15 seconds for intubation or more than 1 attempts of Laryngoscopy Patients taking medicines that affect the heart rate such as clonidine,beta –blockers Patients undergoing emergency surgeries will be excluded from the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the efficacy of nebulised Dexmedetomidine given pre- operatively to attenuate Hemodynamic response to laryngoscopy and Endotracheal intubation. Before laryngoscopy,After laryngoscopy,1 min,5 min,10 min After intubation
- Secondary Outcome Measures
Name Time Method To calculate total amount of Propofol used during induction of General Anesthesia & Fentanyl during surgery For Propfol at baseline & for Fentanyl after 1 hr to end of surgery
Trial Locations
- Locations (1)
Hamidia Hospital
🇮🇳Bhopal, MADHYA PRADESH, India
Hamidia Hospital🇮🇳Bhopal, MADHYA PRADESH, IndiaDr Nishchitha Reddy SVPrincipal investigator8618428987Svnishchithareddy@gmail.com