Evaluation of nebulised Dexmedetomidine to attenuate hemodynamic response to laryngoscopy and endotracheal intubation
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 96
- Locations
- 1
- Primary Endpoint
- To evaluate the efficacy of nebulised Dexmedetomidine given pre- operatively to attenuate Hemodynamic response to laryngoscopy and Endotracheal intubation.
Study Overview
Brief Summary
Dexmedetomidine in various doses and routes has been studied such as intravenous, intranasal, intramuscular to decrease the hemodynamic response to laryngoscopy and Endotracheal intubation.
However,intravenous administration may cause bradycardia and hypotension and intranasal administration may be associated with irritation.
This studt is about how Nebulised Dexmedetomidine may offer an alternative to both intravenous as well as intranasal routes of administration,since the drug deposition following nebulization takes place over nasal, buccal as well as respiratory mucosa. The nasal mucosa accounts for 65% of the bioavailability of nebulised Dexmedetomidine,while buccal mucosa accounts for 82%.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Not Applicable
Eligibility Criteria
- Ages
- 20.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients of ASA grade I and ASA grade II Age group
- •60 years MPG I and II BMI less than 35.
Exclusion Criteria
- •Patient refusal Patients requiring more than 15 seconds for intubation or more than 1 attempts of Laryngoscopy Patients taking medicines that affect the heart rate such as clonidine,beta –blockers Patients undergoing emergency surgeries will be excluded from the study.
Outcomes
Primary Outcomes
To evaluate the efficacy of nebulised Dexmedetomidine given pre- operatively to attenuate Hemodynamic response to laryngoscopy and Endotracheal intubation.
Time Frame: Before laryngoscopy,After laryngoscopy,1 min,5 min,10 min After intubation
Secondary Outcomes
- To calculate total amount of Propofol used during induction of General Anesthesia & Fentanyl during surgery(For Propfol at baseline & for Fentanyl after 1 hr to end of surgery)