Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

Phase 2

Recruiting

• Conditions: Retinitis Pigmentosa (RP); Usher Syndrome Type 2; Deaf Blind; Retinal Disease; Eye Diseases, Hereditary; Eye Disorders Congenital; Vision Disorders
• Interventions: Drug: Intravitreal Injection of Ultevursen; Other: No intervention, will not receive any active study intervention

• Registration Number: NCT06627179
• Lead Sponsor: Laboratoires Thea

Brief Summary

The purpose of this Phase 2b study is to evaluate the safety and tolerability of Ultevursen administered via intravitreal injection (IVT) in subjects with Retinitis Pigmentosa (RP) due to mutations in exon 13 of the USH2A gene. This is a multicenter Double-masked, Randomized, Sham-controlled study which will enroll 81 subjects.

Detailed Description

A total of eighty-one (81) RP participants will be enrolled in this study, randomized in a 2:1 ratio to either Ultevursen or sham procedure, respectively. Subjects randomized to the active treatment group will receive therapy with Ultevursen administered via intravitreal (IVT) injection to the treatment eye (TE) on Day 1 and at Months 6, 12, and 18. Subjects randomized to sham will undergo a sham procedure in the TE at the corresponding timepoints.

Study Timeline

• Study First Submitted: 2024-09-25
• Study First Submitted QC: 2024-10-02
• Study First Posted: 2024-10-04
• Status Verified: 2024-12
• Study Start: 2024-12-11
• Last Update Submitted: 2024-12-13
• Last Update Posted: 2024-12-18
• Primary Completion: 2027-12
• Study Completion: 2027-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

1. An adult (≥18 years) willing and able to provide informed consent for participation prior to performing any study related procedures OR A minor (8 to less than 18 years) able to provide age-appropriate assent for study participation with a parent or legal guardian willing and able to provide written permission for the subject's participation prior to performing any study related procedures.
2. Both eyes exhibit clinical presentation consistent with RP involving Usher syndrome type 2 or NSRP based on ophthalmic, audiologic, or vestibular examinations. At screening, the Investigator will make the clinical diagnosis of "Usher syndrome type 2a," defined as RP with congenital hearing loss, or "non-syndromic RP," defined as RP without congenital hearing loss.
3. A molecular diagnosis of biallelic disease causing variants (pathogenic or likely pathogenic) in the USH2A gene where at least one of the variants is located on exon 13. A historic genotyping report from a certified laboratory is acceptable with Sponsor approval.
4. Clearly visible and measurable EZ width of ≥2.5 mm in both horizontal and vertical scans in both eyes as measured by SD-OCT and based on the assessment of the CRC.
5. BCVA ≥55 letters based on ETDRS (equivalent to 20/80 based on Snellen notation, or logarithm of the minimum angle of resolution [logMAR] +0.6) in both eyes.
6. Impairment of VF as assessed by SP with a mean sensitivity greater than 4 decibels (dB) and less than 25 dB measured by a V4e target size in the TE.
7. Mean sensitivity greater than 2 dB as determined by MP in the TE.
8. Symmetry of baseline disease in both eyes, defined as the mean BCVA (based on ETDRS) of one eye within ≤10 letters of the mean BCVA of the other eye at screening. If this is not present, the Investigator should discuss the case with the Medical Monitor to decide whether it is appropriate for the subject to participate in the study. For purposes of determining symmetry, the mean BCVA for each eye will be calculated using all BCVA measures obtained during the screening period.

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Exclusion Criteria

1. Presence of additional non-exon 13 USH2A pathogenic or likely pathogenic variant on the USH2A allele carrying the exon 13 mutation in subjects who have one exon 13 disease causing variant and one non-exon 13 disease causing variant.
2. Presence of additional non-exon 13 USH2A pathogenic mutation(s) on both USH2A alleles in subjects who have biallelic exon 13 mutations.
3. Presence of pathogenic or likely pathogenic variants in genes (other than the USH2A gene) which are known to be associated with other inherited retinal degenerative diseases or syndromes. Specifically, the presence of homozygous or compound heterozygous known disease-causing mutations in other genes involved in recessive retinal dystrophies, or the confirmed presence of a known single disease-causing variant in genes involved in dominant, X-linked, or mitochondrial retinal dystrophy genes is exclusionary.
4. At screening, the EZ horizontal or vertical width are outside the field of the SD-OCT scan based on the assessment of the CRC.
5. Presence of any significant ocular or non-ocular disease/disorder (including medication and laboratory test abnormalities) which, in the opinion of the Investigator and with concurrence of the Medical Monitor, may either put the subject at risk because of participation in the study, may impact the subject's ability to participate in the study, or may interfere with assessment of efficacy and safety in the study.
6. Presence of unstable concurrent cystoid macular edema (CME), or subject started on (or changed dose of) topical or systemic carbonic anhydrase inhibitor treatment in the 3 months prior to enrollment. CME is allowed if stable for 3 months (with or without treatment). However, stable CME that disrupts the EZ width measurement, as determined by CRC, is an exclusion.
7. Receipt of any prior intraocular or periocular surgery or planned intraocular surgery or procedure during the study. Subjects may be considered for inclusion if there are no clinically significant complications of surgery present and following approval by the Medical Monitor.
8. Receipt of any IVT injection prior to study entry. However, subjects who have received a prior IVT injection may be considered for inclusion following approval by the Medical Monitor.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ultevursen 180/60 μg	Intravitreal Injection of Ultevursen	Subjects will receive an intravitreal injection (IVT) of Ultevursen with concentrations of 3.6 mg/mL for initial dose and 1.2 mg/mL for maintenance doses every 6 months thereafter through Month 18 (up to 4 doses).
Sham Procedure	No intervention, will not receive any active study intervention	Sham-procedure (no experimental drug administered)

Primary Outcome Measures

Name	Time	Method
To evaluate efficacy after 24 months of treatment	24 Months	Annualized percent change from baseline in ellipsoid zone (EZ) width as measured by spectral-domain optical coherence tomography (SD-OCT) up to Month 24.

Secondary Outcome Measures

Name	Time	Method
Change in retinal sensitivity measured by static perimetry (SP)	Months 12 and 24
Change in retinal sensitivity measured by microperimetry (MP)	Months 12 and 24
Change from baseline in low luminance visual acuity (LLVA) using the Early Treatment Diabetic Retinopathy Study (ETDRS) chart	Months 12 and 24
Change from baseline in best-corrected visual acuity (BCVA) using the ETDRS chart	Months 12 and 24
Percent change from baseline in EZ area by SD-OCT	Months 12 and 24
Percent change from baseline in EZ width by SD-OCT	Months 12 and 24
Change from baseline in virtual visual maze performance score	Months 12 and 24
Change from baseline in dark-adapted full-field stimulus threshold (FST) testing	Months 12 and 24
Incidence of anti-drug antibodies (ADAs) against ultevursen	Months 12 and 24
Systemic Exposure	Months 12 and 24	Systemic serum concentration of ultevursen.
Frequency and severity of ocular and non-ocular adverse events (AEs)	From enrollment to the end of treatment(up to 24 months)
Change from baseline in the Michigan Retinal Degeneration Questionnaire (MRDQ) for subjects ≥13 years of age	Months 12 and 24
Change from baseline in the Michigan Vision-Related Anxiety Questionnaire (MVAQ) for subjects ≥13 years of age	Months 12 and 24

Trial Locations

Locations (1)

Retina Foundation of the Southwest; 🇺🇸 Dallas, Texas, United States