WSI Based DL for Diagnosing the IASLC Grading System of Lung Adenocarcinoma

Recruiting

• Conditions: Lung Adenocarcinoma; Whole Slide Image; IASLC Grading System; Artificial Intelligence

• Registration Number: NCT05925764
• Lead Sponsor: Shanghai Pulmonary Hospital, Shanghai, China

Brief Summary

The purpose of this study is to evaluate the performance of a whole slide image based deep learning model for diagnosing the IASLC grading system in resected lung adenocarcinoma based on a multicenter prospective cohort.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-05-12
• Study First Submitted QC: 2023-06-27
• Study First Posted: 2023-06-29
• Status Verified: 2024-10
• Study Start: 2024-10-15
• Last Update Submitted: 2024-10-17
• Last Update Posted: 2024-10-21
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Age ranging from 18-85 years old;
2. Pathological confirmation of primary lung adenocarcinoma after surgery;
3. Obtained written informed consent.

Exclusion Criteria

1. Multiple lung lesions;
2. Poor quality of whole slide images;
3. Mucinous adenocarcinomas and variants;
4. Participants who have received neoadjuvant therapy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Agreement rate of the IASLC grading system	2024.11.01-2024.12.31	Agreement rate between the deep learning model and pathologists in diagnosing the IASLC grade of lung adenocarcinoma.

Secondary Outcome Measures

Name	Time	Method
Agreement rate of the predominant subtypes	2024.11.01-2024.12.31	Agreement rate between the deep learning model and pathologists in diagnosing the predominant growth patterns of lung adenocarcinoma.

Trial Locations

Locations (3)

Affiliated Hospital of Zunyi Medical University; 🇨🇳 Zunyi, Guizhou, China

The First Affiliated Hospital of Nanchang University; 🇨🇳 Nanchang, Jiangxi, China

Ningbo HwaMei Hospital; 🇨🇳 Ningbo, Zhejiang, China