跳至主要内容
临床试验/NCT05411250
NCT05411250Unknown不适用

Early Diagnosis of Therapy-associated Cardiotoxicity Basing on PET/CT in Lymphoma

Peking University Cancer Hospital & Institute0 个研究点目标入组 40 人开始时间: 2022年6月1日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
40
主要终点
SUVmax

研究概览

简要总结

To explore the value of 18F-fluorodeoxyglucose (FDG) PET/CT imaging in early diagnosis of treatment-related cardiotoxicity (TACT) of lymphoma using visual method and semi-quantitative method.

详细描述

First of all, the cardiac 18F-FDG uptake in patients with lymphoma will be observed by visual method: according to the uptake site, it will be divided into left ventricular uptake and biventricular uptake, and according to the degree of uptake, it will be divided into equal uptake (myocardial uptake is lower than cardiac blood pool uptake), moderate uptake (myocardial uptake is between cardiac blood pool uptake and liver uptake) and high uptake (myocardial uptake is higher than liver uptake). According to the uptake pattern, it can be divided into diffuse and segmental uptake.Then,using the region of interest method to mesure the value of myocardial uptake of 18F-FDG.The difference value of heart's SUVmax (Δ SUVmax- heart) and% Δ SUVmax- heart before and after chemotherapy or immunotherapy will be calculated. And SUVmax- heart / SUVmax- mediastinum ratio, SUVmax- heart / SUVmax- liver ratio and SUVmax- heart / SUVmax- background ratio (left gluteal muscle) after treatment. Taking the abnormality of ECG (early TACT) as the end point.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • No previous history of heart disease.
  • normal echocardiography, ECG and laboratory tests (creatine kinase, myoglobin, troponin, brain natriuretic peptide) before treatment.
  • 3.18F-FDG PET/CT examination before and after treatment

排除标准

  • 1.receiving radiotherapy and chemotherapy at the same time. 2.previous chest radiotherapy.
  • with severe hepatic or renal dysfunction.

结局指标

主要结局

SUVmax

时间窗: 150 days

the standardized uptake value

次要结局

  • SUVR(150 days)

研究者

发起方
Peking University Cancer Hospital & Institute
申办方类型
Other
责任方
Principal Investigator
主要研究者

Xuejuan Wang,MD

Principal INvestigaor

Peking University Cancer Hospital & Institute

相似试验

Early Diagnosis of Therapy-associated Cardiotoxicity... | 临床试验