Study to derive and understand the characteristic of plaque formation and outcome of Coronary Angioplasty in patients with acute coronary syndrome, through Intra-vascular Ultrasound

Not Applicable

Conditions: Health Condition 1: I249- Acute ischemic heart disease, unspecified

Registration Number: CTRI/2021/09/036845

Lead Sponsor: Society for Coronary Imaging and Physiology SCIP

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Patients who are undergoing IVUS guided PCI for diagnosis of

1)ST elevation myocardial infarction (STEMI): Defined as chest pain with > 1mm STE in 2 contigous leads except V2 & V3. In V2 & V3, STE of > 2mm in males & > 1.5mm in females

2)Non ST elevation myocardial infarction (NSTEMI): Defined as chest pain with ECG changes consistent with new ischemia ( ST depression , T inversions ) with troponin elevation

3. Unstable angina: Defined as chest pain at rest or minimal effort with or without ECG changes and no biomarker elevation

Exclusion Criteria

1)cardiogenic shock - as defined by SBP < 90mmHg (/ need for inotropic support to maintain perfusion ) + evidence of end organ hypoperfusion - altered sensorium / oliguria

2)Hemodynamic instability - as defined by recurrent VT / acute pulmonary oedema / need for ventilator support / mechanical cardiac support - or any instance where operator feels performing imaging is not possible due to clinical instability

3)Stent thrombosis / restenosis - any stent failure related vessel

4)Graft interventions

5)Inability to perform either pre or post IVUS images

6)Mechanical complications

7)Planned CABG in next 30 days

8)Severe comorbidities which restrict life span to < 1 year

9)Presenting eGFR < 30 ml/min/m2

10)Age < 18 & >90 years

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. TIMI flow 2 at end of procedure <br/ ><br> <br/ ><br>2. Target lesion revascularisation at any time point ( inhospital, 30 days, 6months)Timepoint: 1. TIMI flow 2 at end of procedure <br/ ><br> <br/ ><br>2. Target lesion revascularisation at any time point ( inhospital, 30 days, 6months)

Secondary Outcome Measures

Name	Time	Method
Echo derived LV function ( ejection fraction)Timepoint: end of procedure, at 30 days and 6 months;Incidence of adverse eventsTimepoint: end of procedure, at 30 days and 6 months;Incidence of cardiac death, MI, target lesion revascularisation, any unplanned revascularisation and LV function (extended followup)Timepoint: at 1 year;IVUS analysis of plaque morphologyTimepoint: inhospital, 30 days & 6 months;MACE (cardiac death, MI and need for repeat target lesion revascularisation ( TLR), any unplanned revascualrisation)Timepoint: inhospital, 30 days & 6 months