Describe Relations Between qCON and qNOX Indicies During Propofol-Remifentanil General Anesthesia

Recruiting

• Conditions: Anesthesia Brain Monitoring

• Registration Number: NCT06349681
• Lead Sponsor: University of Padova

Brief Summary

CONOX is a neuromonitoring EEG- device for sedation (qCON) and analgesia (qNOX) monitoring during general anesthesia.

It is unknown on how the indicies can differentiate themselves so aim of this study is to determine the relationship bewtween the 2 indicies.

Detailed Description

CONOX is a neuromonitoring EEG- device for sedation (qCON) and analgesia (qNOX) monitoring during general anesthesia.

It is unknown on how the indicies can differentiate themselves so aim of this study is to determine the relationship bwtween the 2 indicies, as well as with EMG, Concentration of Propofol (CeP) and Remifentanil (CeR) during Total Intravenous Anesthesia with Target Controlled Infusion (TIVA-TCI).

Study Timeline

• Study First Submitted: 2024-03-24
• Study First Submitted QC: 2024-03-29
• Status Verified: 2024-04
• Study Start: 2024-04-01
• Study First Posted: 2024-04-05
• Last Update Submitted: 2024-04-24
• Last Update Posted: 2024-04-25
• Primary Completion: 2024-09-01
• Study Completion: 2024-10-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 14

Inclusion Criteria

• Undergo general anaesthesia with Targeted Controlled Infusion of Propofol (Eleveld or Schnider model) and Remifentanil (Minto model) and CONOX monitoring

Exclusion Criteria

• Neurological disease
• Psychiatric disease
• Obesity
• Locoregional anesthesia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between qCON and qNOX	CONOX values will be recorded from start of anesthesia to the return of responsiveness at the end of surgery	qCON and qNOX values from CONOX monitor will be compared

Secondary Outcome Measures

Name	Time	Method
Correlation between qCON and concentrations of Propofol(CeP)	CONOX and TCI values will be recorded from start of anesthesia to the return of responsiveness at the end of surgery	qCON and CeP values from CONOX monitor and infusion pump will be compared
Correlation between qNOX and concentrations of Remifentanil (CeR)	CONOX and TCI values will be recorded from start of anesthesia to the return of responsiveness at the end of surgery	qNOX and CeR values from CONOX monitor and infusion pump will be compared

Trial Locations

Locations (1)

Treviso Regional Hospital; 🇮🇹 Treviso, TV, Italy