Effects of Transcranial Direct Current Stimulation on Primary Cortex and Prefrontal Dorsolateral Cortex in Pain Processing on Healthy Volunteers: A Triple Blind Randomized Controlled Trial.

Universidad Rey Juan Carlos1 site in 1 country30 target enrollmentJune 6, 2020

ConditionsPain Processing in Healthy Volunteers

Overview

Phase: N/A
Intervention: Not specified
Conditions: Pain Processing in Healthy Volunteers
Sponsor: Universidad Rey Juan Carlos
Enrollment: 30
Locations: 1
Primary Endpoint: Pain pressure algometer temporal summation
Status: Completed
Last Updated: 5 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to evaluate the effects of a direct current applied transcranial over two cortical areas on healthy volunteers' pain processing.

Registry

clinicaltrials.gov

Start Date

June 6, 2020

End Date

July 25, 2020

Last Updated

5 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

Universidad Rey Juan Carlos

Responsible Party

Principal Investigator

Josue Fernandez Carnero

Associate Professor

Universidad Rey Juan Carlos

Eligibility Criteria

Inclusion Criteria

•Age between 18 and 40 years
•Comprehension of the study tasks

Exclusion Criteria

•Presence of pain in the previous 6 months
•Altered sensitivity in the tested regions
•Intolerance to electrotherapy
•Presence of pacemakers or any other implanted device
•Ulcers or scars in the skin at the location of the electrodes
•Treatment with direct current stimulation within one week
•Pregnancy
•Frequent headaches
•History of neuromuscular disease
•Previous clinical history of cervical surgery

Outcomes

Primary Outcomes

Pain pressure algometer temporal summation

Time Frame: Pre-intervention and immediately after treatment

Change in pain perceived between the first and tenth painful pressure stimulus

Conditioned Pain Modulation

Time Frame: Pre-intervention and immediately after treatment

Pain pressure threshold change after a painful ischemic stimulus

Secondary Outcomes

Neural mechanosensitivity(Pre-intervention and immediately after treatment)
Pain pressure threshold(Pre-intervention and immediately after treatment)
Pain pressure tolerance(Pre-intervention and immediately after treatment)
Cold hyperalgesia with a cold pack(Pre-intervention and immediately after treatment)
Isometric grip strength(Pre-intervention and immediately after treatment)