Effect Of Rural-Urban Settings And Parasitic Infections On The Immune System And Vaccination Responses: A Study In Kilimanjaro And Arusha Regions In Tanzania

Kilimanjaro Christian Medical Centre KCMC0 个研究点目标入组 200 人开始时间: 2024年4月29日最近更新: 2024年5月27日

试验速览

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•1.People who are permanent residents of the selected areas and expected to stay during the whole duration of the study
•2.Aged 18-35 years
•3.Accepted written consent

•1.Clinically significant history of diseases like HIV, TB, Cancer, Cardiovascular diseases, gastrointestinal disease, liver disease, renal disease, an endocrine disorder, or neurological illness.
•2.History of recurrent infections and being admitted 2 or more times a year at hospital and receiving antibiotics as it will be shown in discharge summary.
•3.History of long-term use of corticosteroids for any reasons, i.e. concurrent oral or systemic steroids medication or the concurrent use of other immunosuppressive agents within 2 to 3 months before enrolment.
•4.Hospital admission in the past 3 months
•5.Any history of being the recipient of vaccines that will be used during the study
•6.Positive HIV serology
•7.Haemoglobin levels less than 8.5 g/dl
•8.A positive pregnancy test at the start or during the study
•9.History of nose bleeding
•10.Female currently lactating
•11.Transfusion of blood products within three months before the study
•12.Received immunoglobulins within three months before the study
•13.Low blood pressure =90/60 mm Hg
•14.High blood glucose >7.1 mmol l-1 fastings or >11.1 mmol l-1 random RBG

发起方

Kilimanjaro Christian Medical Centre KCMC