Acute effects of ketamine on the glutamatergic NMDA receptor quantified by PET and the radioligand (R)-[11C]-Me-NB1 - Ketamine, acute effects

Medical University of Vienna0 个研究点目标入组 24 人开始时间: 2022年12月5日最近更新: 2024年2月19日

试验速览

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•- General health based on medical history, physical examination and structured clinical interview for DSM-V (SCID)
•- Age 18 to 55 years
•- Willingness and competence to sign the informed consent form
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 55
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•- Current or history of psychiatric or neurological disease
•- Current medical illness requiring treatment
•- Current or former psychopharmacological treatment
•- Pregnancy or currently breastfeeding
•- Current or former substance abuse
•- Any contraindication for MRI e.g. (implants, stainless steel graft)
•- Failure to comply with the study protocol or to follow the instruction of the investigating team
•- If the radiation exposure by PET or SPECT or CT during scientific study participation in the last 10 years exceeds 30 mSv

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