Sublingual Administration is More Fast Than Oral or IV Administration in PPI Dosing With Respect to Intragastric pH and Therapeutic Effectiveness: a Prospective, Randomized, Controlled Trial
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Measure 24-hour intragastric pH
Study Overview
Brief Summary
Compare 24-hour intragastric pH and therapeutic effectiveness of proton pump inhibitor (PPI) among different administration methods: per oral (PO), intravenous (IV), and sublingual (SL).
Detailed Description
Intragastric pH and therapeutic effectiveness of PPI was compared among patients given PPI with different administration methods. 24 hour intragastric pH catheter was inserted in stomach of patients with peptic ulcer an hour prior to PPI administration in order to observe the initial change in pH. Three groups of patients were given PPI through per oral, intravenous, and sublingual administration methods. The hypothesis of this study is that sublingual administration will be faster than oral or IV administration in PPI dosing with respect to intragastric pH change and re-bleeding rate.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 20 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with peptic ulcer disease
- •Age: 20-75 years old
- •Patients who submitted informed consent
Exclusion Criteria
- •Peptic ulcer disease with spurting and oozing
- •Shock, hypotension, pregnancy
- •Gastrointestinal malignancy
Outcomes
Primary Outcomes
Measure 24-hour intragastric pH
Time Frame: 24 hours
Secondary Outcomes
No secondary outcomes reported
Investigators
Jin Il Kim
MD, PhD
The Catholic University of Korea