Study of Oral Vitamin D Treatment for the Prevention of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 1,500
- 主要终点
- Change in serum levels of 25-hydroxy vitamin D
研究概览
简要总结
The purpose of this study is to determine whether vitamin D is effective in the prevention of hepatocellular carcinoma in those patients with chronic hepatitis B.
详细描述
Potential participants will be identified from the follow-up cohort of chronic hepatitis B in the third Affiliated Hospital of Sun Yat-sen University (3rd SYSU). The hepatologists at the 3rd SYSU's Infectious Disease Institute will ask each potential participant if she/he is interested in participating. If the patient expresses an interest in the study, one of the researchers will meet with the patient when he/she is at the 3rd SYSU for a regular appointment and will describe the study to the potential participant. If a patient continues to be interested in participating, she/he will be given a copy of the review board approved consent document to read. The consent document will be used as a guide for explaining the study in detail to the patient. The participant allocated to the experimental group will be contacted by one of the investigators on the research team and instructed to begin taking 2 tablets per day (800 IU total) of vitamin D3 besides their regular anti-virus treatment. Those patients allocated in the control group will be informed that they are not to take any vitamin D3 and they will be followed as controls for this study. The researcher will investigate general treatment benefits and the potential to reduce the development of Hepatocellular carcinoma (HCC), also known as liver cancer. Improvement of treatment benefits will be determined by interviews with patients, the level of HBsAg and HBeAg, the development of liver fibrosis and evidence of HCC on routine imaging.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All subjects between the ages of 18 and 70 with chronic hepatitis B and under the oral anti-virus treatment followed at the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, will be offered entry into this study. The diagnosis of chronic Hepatitis B will be based on that they had been positive for hepatitis B surface antigen (HBsAg) for at least six months, and were positive for HBeAg or negative for HBeAg with detectable HBV DNA at screening.
- •No evidence of HCC on entry imaging study.
- •Model for End Stage Liver Disease (MELD) score under 22 (a MELD score over 22 would predict a 3 month mortality rate of approximately 20%).
- •Not currently participating in another intervention study.
- •Not pregnant or lactating, and willing to use effective contraception during study period.
- •Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule.
- •Ability to provide written informed consent according to national/local regulations.
排除标准
- •evidence of hepatocellular carcinoma within 6 months after enrollment,
- •a serum alanine aminotransferase level more than 10 times the upper limit of normal,
- •an elevated serum creatinine level,
- •any diagnosis of kidney stones,
- •a diagnosis of hyperparathyroidism or other serious disturbance of calcium metabolism in the past 5 years,
- •any evidence of autoimmune hepatitis, coinfection with hepatitis C or D virus or human immunodeficiency virus,
- •other serious concurrent illness (e.g., alcoholism, uncontrolled diabetes, or cancer),
- •treatment with immunomodulatory within the 6 months before screening,
- •treatment with any investigational drug within the 30 days before the study began.
研究组 & 干预措施
Vitamin D
Drug: Vitamin D3 800 IU daily besides the anti-virus treatment with nucleos(t)ide medicine
干预措施: Vitamin D3 (Drug)
结局指标
主要结局
Change in serum levels of 25-hydroxy vitamin D
时间窗: at baseline, and at 6 and 12 months
Change in serum levels of 25-hydroxyvitamin D at 6 months and 12 months compared to baseline
次要结局
- Change in serum creatinine(at baseline, and at 6 and 12 months)
- Number of participants on Vitamin D treatment with adverse events(1 year)
- Change in fibrosis score(at baseline, and at 6 and 12 months)
研究者
Yutian Chong
Professor
Third Affiliated Hospital, Sun Yat-Sen University