Assessment of platelet rich plasma intraarticular injection in clinical outcome and MRI findings in knee osteoarthritis

Physical Medicine and Rehabilitation Department of Shahid Beheshti University of Medical Sciences0 个研究点目标入组 40 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

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•arthralgia since past 3 months; radiologic evidence of articular damage (grade 1-4 of Kellgren-Lawrence scale) based on knee OA criteria of ACR. Exclusion criteria: systemic diseases such as diabetes mellitus and collagen vascular disorders; history or presence of cancer or malignant disorders; any infection and active wound of the knee; presence of immunosuppressive, autoimmune and platelet disorders; treatment with anticoagulant and anti-platelet medications 10 days before injection; use of NSAIDs 2 days before injection; history of knee articular injections of corticosteroids 3 weeks or use of systemic corticosteroids 2 weeks before PRP injections; hemoglobin measures of less than 12 g/dl and platelet counts of less than 150,000 per micro liter; recent history of severe trauma to the knee; age less than 45 or over 75 year; history of vasovagal shock; pregnancy; breastfeeding; genu valgum/varum greater than 20 degrees; contraindication for MRI including aneurysm clips,pacemaker,metallic devices and claustrophobia.

发起方

Physical Medicine and Rehabilitation Department of Shahid Beheshti University of Medical Sciences