Use of Dual Energy Computed Tomography in Thoracic Radiotherapy Planning.

Completed

• Conditions: Radiation Pneumonitis; Lung Function Decreased; Lung Cancer

• Registration Number: NCT04863027
• Lead Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Brief Summary

This is a prospective observational study aiming: 1) To quantify lung function using perfusion dual energy computed tomography (DECT) and use this information at the time of treatment planning with preferential sparing of functional lung parenchymal 2) to validate results of lung function obtained using DECT with lung perfusion scintigraphy results, the current standard method; 4) to compare dosimetry of whole lungs vs. functional lungs in patients treated with either stereotactic body radiotherapy (SBRT) for early stage lung cancer or conventional radiotherapy for locally advanced lung cancer and 5) to evaluate lung function 6, 12 and 24 months post-radiotherapy with both perfusion DECT and pulmonary function tests and compare radiation dose-map to functional lung-map.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01
• Study First Submitted: 2021-03-29
• Study First Submitted QC: 2021-04-24
• Study First Posted: 2021-04-28
• Status Verified: 2022-11
• Primary Completion: 2022-11
• Study Completion: 2022-11
• Last Update Submitted: 2022-11-11
• Last Update Posted: 2022-11-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ≥ 18 years
• ECOG 0-2
• Pulmonary neoplasia, confirmed histopathologically or by imaging
• Prognosis evaluated ≥ 1 year by attending MD
• Clinically acceptable lung capacity to undergo radiotherapy
• Initial assessment including history, physical examination, biochemistry, PFT, chest radiograph, chest and abdominal-pelvic scan, PET
• Written consent
• The patient must be available for treatment and monitoring. Patients registered in the study should be treated in our center.

Exclusion criteria

• Previous radiotherapy in the radiation field
• Presence of any major medical condition that, in the opinion of the investigator, would prevent follow-up at 6, 12 and 24 months post-radiotherapy.
• Iodine allergy
• Pregnancy and lactation

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Lung function quantification at baseline	Baseline	To quantify lung function using perfusion DECT and use this information at the time of treatment planning with preferential sparing of functional lung parenchyma.
Radiation-induced lung function damage quantification	at 24 months after radiotherapy	To evaluate lung function post-radiotherapy with both perfusion DECT and pulmonary function tests and compare radiation dose-map to functional lung-map.

Trial Locations

Locations (1)

Centre Hospitalier de l'Université de Montréal; 🇨🇦 Montréal, Quebec, Canada