The effect of preoperative vitamin D administration on postoperative serum levels of Interleukin 1, Interleukin 6 and Tumor Necrosis Factor-alpha in patients undergoing elective CABG
Phase 3
- Conditions
- coronary artery bypass graft.Atherosclerotic heart disease
- Registration Number
- IRCT201502022804N7
- Lead Sponsor
- Vice chancellor for research, Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Age 40-75; elective Coronary Artery Bypass Graft with CardioPulmonary Bypass; constant surgeon
Exclusion criteria:
informed written consent; diabetes mellitus; chronic kidney disease causing serum Cr>2mg/dL; hepatic failure causing liver function test failure; high levels of vitamin D; off pump Coronary Artery Bypass Graft; any unwanted complication in the operation period; re-starting CPB after weaning from bypass; Pulmonary artery pressure >30 before operation; Ejection Fraction<30%; re-operation in the postoperative period
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum cytokines after CABG. Timepoint: serum cytokines are measure preoperatively as baseline and the after operation. Method of measurement: serum levels detected by ELISA.
- Secondary Outcome Measures
Name Time Method Duration of surgery. Timepoint: duration of anesthesia. Method of measurement: cardiopulmonary bypass time.