The influence of tear film stability on visual function, accommodative microfluctuations and scattering

Not Applicable

• Conditions: Dry eye

• Registration Number: JPRN-UMIN000014536
• Lead Sponsor: Dry eye society

Brief Summary

Part 1 Mean blink frequency and High frequency component 1 values in accommodative micro-fluctuation measurements were significantly higher in the dry eye group than they were in the non-dry eye group. Part 2 Diquafisol ophthalmic solution (DQS) significantly improved tear break up time (BUT) and tear meniscus height (TMH) scores, while artificial tears (AT) significantly improved tear BUT but not TMH score. Mean perception of pain and dry eye symptom scores were lower after medication use in the DQS and AT groups. However, perception of touch did not significantly change in either group. A positive correlation was observed between the improvement degrees of perception of pain and dry eye symptoms in the overall study subjects. https://www.ncbi.nlm.nih.gov/pubmed/29671255

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-07-20
• Study Completion: 2015-01-11
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

Not provided

Exclusion Criteria

Part1 ;any eye disease that may influence of the assessment of the study ;any conditions that may influence of the assessment of the study Part2-1;any eye disease that may influence of the assessment of the study ;any conditions that may influence of the assessment of the study Part2-2 ;any eye disease that may influence of the assessment of the study ;any conditions that may influence of the assessment of the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Part1 Visual function Accommodative microfluctuations Scattering Part2-1 Visual function Accommodative microfluctuations Scattering Subjective symptoms(only eye fatigue) Part2-2 Visual function Accommodative microfluctuations Scattering Subjective symptoms(only eye fatigue)

Secondary Outcome Measures

Name	Time	Method
Part1 Subjective symptoms Dry eye inspection item Part2-1 Subjective symptoms(except eye fatigue) Dry eye inspection item Part2-2 Subjective symptoms(except eye fatigue) Dry eye inspection item