Red cell distribution width as a predictor of mortality in critically ill patients with Acute Respiratory failure requring mechanical ventilation in Respiratory intensive care unit in a Teritiary care teaching hospital -A Prospective observational study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To assess red cell distribution width at admission as a marker to predict mortality in patients with Acute Respiratory Failure requiring mechanical ventilation
研究概览
简要总结
Acute Respiratory Failure is a common critical clinical syndrome in Intensive care units caused by multitide of pathological state with a mortality of about 36 %
Acute Respiratory Failure implies an inability to maintain adequate oxygenation to tissues or adequate removal of co2 from tissues
Red cell distribution width (rdw) is a measure of variation in red blood cell volume that is routinely reported in complete haemogram ,any process that realeses reticulocytes into the circulation will result in an increase in Red cell distribution width
Transient decrease in oxygen partial pressure will lead to pulsed erythropoietin release through hypoxia inducible transcription factors ,these inturn release of immature reticulocytes into circulation leading to anisocytosis and higher rdw
elevated RDW at admission was associated with early mortality and worse longterm outcome
RDW will be measured in patient with acute respiratory failure requiring mechanical ventilation within 6 hrs of intubation and after 48 hours of intubation and will be compared to APACHE II ans SOFA score which were measured at admission and 48 hours for predicting mortality
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •All adult patients of more than 18 years of age Patients with acute respiratory failure who require mechanical ventilation and get admitted to respiratory intensive care unit Patients who develop acute resoiratory failure during stay in respiratory intensive care unit and require mechanical ventilation.
排除标准
- •Patients unwilling to participate in the study Pregnancy and Lactating women Patients who were intubated elsewhere and shifted to our hospital Patients who transferred to another intensive care and lost follow up Length of stay less than 24 hrs in Respiratory intensive care unit White blood cell count less than 1000cells/ml Solid or Haematological tumour requiring immune supression and outpatient steroid or radiotherapy History of packed RBC transfution in the previous week.
结局指标
主要结局
To assess red cell distribution width at admission as a marker to predict mortality in patients with Acute Respiratory Failure requiring mechanical ventilation
时间窗: To assess red cell distribution width at admission that is base line and 48 hours after admission as a marker to predict mortality in patients with Acute Respiratory Failure requiring mechanical ventilation
次要结局
- 1.To compare the Red cell distribution width with well known scoring systems (apache ii,SOFA)in predicting mortality(To study the change in rdw at 48 hours in predicting the outcome of patients)
研究者
Bhavana Dhakshinapu
Sri Venkateswara Institute Of Medical Sciences