Tumor Mutational Patterns and Infiltrating Lymphocyte Density in Young and Old Patients With Breast Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 345
- 主要终点
- Assessment of the prevalence of gene mutations in women <=35 years old with early breast cancer.
研究概览
简要总结
Age may pertain to different tumor genotype characteristics which may interfere with treatment efficacy and prognosis. The investigators investigated the distribution and prognostic effect of mutations (mut) and tumor infiltrating lymphocyte (TILs) in young and elderly early breast cancer patients (pts).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women with early breast cancer <35 years old or >65 years old
排除标准
- 未提供
结局指标
主要结局
Assessment of the prevalence of gene mutations in women <=35 years old with early breast cancer.
时间窗: Up to 13 years
Assessment of the prevalence of gene mutations in women >65years old with early breast cancer.
时间窗: Up to 13 years
Evaluation of Tumor Infiltrating Lymphocytes (TILs) density using descriptive statistics in women <=35 years old with early breast cancer.
时间窗: Up to 13 years
Evaluation of Tumor Infiltrating Lymphocytes (TILs) density using descriptive statistics in women >65 years old with early breast cancer.
时间窗: Up to 13 years
Evaluation of the prognostic effect of gene mutations and Tumor Infiltrating Lymphocytes with respect to Overall Survival in women <=35 years old with early breast cancer
时间窗: Up to 13 years
Evaluation of the prognostic effect of gene mutations and Tumor Infiltrating Lymphocytes with respect to Overall Survival in women >65 years old with early breast cancer.
时间窗: Up to 13 years
次要结局
未报告次要终点
研究者
Manto Nikolaidi
Medical Oncologist
Hellenic Cooperative Oncology Group