Systematic Review And Meta-Analysis Of Psoriasis Treatments.

Completed

• Conditions: Psoriasis

• Registration Number: NCT01425138
• Lead Sponsor: Pfizer

Brief Summary

This project involved a systematic literature review of published trials of treatments for moderate-to-severe plaque psoriasis. Data was extracted from the publications on various psoriasis endpoints including the Physician Global Assessment (PGA), Dermatology Life Quality Index (DLQI), and Short-Form 36 (SF-36). A traditional meta-analysis and a mixed treatment comparison was conducted on the extracted data.

Detailed Description

This project involved a systematic literature review of published trials of treatments for moderate-to-severe plaque psoriasis. Data was extracted from the publications on various psoriasis endpoints including the Physician Global Assessment (PGA), Dermatology Life Quality Index (DLQI), and Short-Form 36 (SF-36). A traditional meta-analysis and a mixed treatment comparison was conducted on the extracted data. We included all published randomized controlled trials of treatments for moderate-to-severe psoriasis that met the study inclusion criteria.

Study Timeline

• Study Start: 2009-06
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Study First Submitted: 2011-08-26
• Study First Submitted QC: 2011-08-26
• Study First Posted: 2011-08-29
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-29
• Last Update Posted: 2018-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

• Randomized controlled clinical trials of treatments for moderate-to-severe plaque psoriasis.
• Trials had to evaluate at least one of the following: Physician's Global Assessment (PGA), Dermatology Life Quality Index (DLQI) and/or the Short-Form 36 (SF-36).

Exclusion Criteria

Observational studies

• Trials that did not report the Physician's Global Assessment (PGA),
• Dermatology Life Quality Index (DLQI) or the Short-Form 36 (SF-36).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Physician Global Assessment (PGA)
Short-Form 36 (SF-36)
Dermatology Life Quality Index (DLQI)

Secondary Outcome Measures

Name	Time	Method
No secondary outcomes	No secondary outcomes