Community based Surveillance to estimate incidence and sero prevalence of acute febrile illness with focus on Dengue and Chikungunya – A prospective multi-centric cohort Study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 752
- 试验地点
- 1
- 主要终点
- Age specific attack rate
研究概览
简要总结
The proposed study is planned with an objective to estimate the incidence of acute febrile illnesses in the community, follow the febrile cases through surveillance to estimate the incidence of Dengue and Chikungunya at community level. The study is planned to be carried among 10 DRIVEN network sites and in 7520 individuals (752 / site). The study will be carried in two phases - Phase 1 - Sero survey - In this two round (Baseline and end line) of sero survey shall be carried for 750 individuals distributed across the ages. In Phase 2 of the study Fever surveillance will be carried where the individual will be tested for Dengue and Chikungunya at different time points. As part of participant care and understand the prevalence of locally endemic diseases the participants shall also be tested for Malaria, Typhoid, Leptospirosis and Scrub typhus.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 2.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •(1) Study will be carried out in individuals above 2 Years of age.
- •(2) Individuals currently residing and likely to stay till the end of one year in the study area.
- •(3) Consented to participate in both sections of the study (Sero Prevalence and AFI Surveillance) and follow all procedures.
排除标准
- •Ongoing fever episodes or history of AFI on or within 3 calendar days before enrolment for the cohort.
结局指标
主要结局
Age specific attack rate
时间窗: 13 Months
Age-specific cumulative incidence of asymptomatic Dengue and Chikungunya infections
时间窗: 13 Months
Age-specific cumulative incidence of symptomatic Dengue and Chikungunya events
时间窗: 13 Months
Age Specific sero prevalence and sero incidence of neutralizing antibodies
时间窗: 13 Months
Symptomatic proportion of cases (asymptomatic fraction)
时间窗: 13 Months
次要结局
- Incidence of Acute febrile Illnesses - Malaria, Typhoid, Leptospirosis and Scrub typhus(13 months)