Acute Febrile Illness Surveillance

Not yet recruiting

• Conditions: Healthy

• Registration Number: CTRI/2023/05/053025
• Lead Sponsor: BIRAC

Brief Summary

The proposed study is planned with an objective to estimate the incidence of acute febrile illnesses in the community, follow the febrile cases through surveillance to estimate the incidence of Dengue and Chikungunya at community level. The study is  planned to be carried among 10 DRIVEN network sites and in 7520 individuals (752 / site). The study will be carried in two phases - Phase 1 - Sero survey - In this two round (Baseline and end line) of sero survey shall be carried for 750 individuals distributed across the ages. In Phase 2 of the study Fever surveillance will be carried where the individual will be tested for Dengue and Chikungunya at different time points. As part of participant care and understand the prevalence of locally endemic diseases the participants shall also be tested for Malaria, Typhoid, Leptospirosis and Scrub typhus.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-06
• Last Update Posted: 2023-05-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 752

Inclusion Criteria

• (1) Study will be carried out in individuals above 2 Years of age.
• (2) Individuals currently residing and likely to stay till the end of one year in the study area.
• (3) Consented to participate in both sections of the study (Sero Prevalence and AFI Surveillance) and follow all procedures.

Exclusion Criteria

Ongoing fever episodes or history of AFI on or within 3 calendar days before enrolment for the cohort.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Age specific attack rate	13 Months
Age-specific cumulative incidence of asymptomatic Dengue and Chikungunya infections	13 Months
Age-specific cumulative incidence of symptomatic Dengue and Chikungunya events	13 Months
Age Specific sero prevalence and sero incidence of neutralizing antibodies	13 Months
Symptomatic proportion of cases (asymptomatic fraction)	13 Months

Secondary Outcome Measures

Name	Time	Method
Incidence of Acute febrile Illnesses - Malaria, Typhoid, Leptospirosis and Scrub typhus	13 months

Trial Locations

Locations (1)

INCLEN SOMAARTH Mawphlang; 🇮🇳 Hills, MEGHALAYA, India

INCLEN SOMAARTH Mawphlang

🇮🇳Hills, MEGHALAYA, India

Dr Abhishek Agarwal

Principal investigator

9582366630

abhishek.agarwal@inclentrust.org