Rapid circadian re-Entrainment to modify Sleep parameters upon acute hypoxic Exposure after jeT lag (RESET): a randomised crossover trial

niversity of Edinburgh0 sites35 target enrollmentNovember 24, 2021

Overview

No summary available.

Registry

who.int

Start Date

November 24, 2021

End Date

September 30, 2022

Last Updated

2 years ago

Study Type

Interventional

Sex

All

Sponsor

niversity of Edinburgh

•1\. Accepted as members of the APEX 6 expedition (aged 18\-25 years; there is no obligation to take part in the research having been accepted on the expedition).
•2\. Able to provide details of registration at a GP surgery.
•3\. In the case of volunteers who regularly attend a medical clinic, confirmation that they have informed the hospital specialist that they intend to participate in the expedition.
•4\. Identify themselves as being healthy.
•5\. Capacity to understand written and verbal information provided in English, and able to provide valid written informed consent to participate.

•1\. Previous admission to hospital with acute asthma
•2\. Significant cardio\-respiratory disease
•3\. Regular cardiovascular medications
•4\. Advised against travel to altitude by GP, relevant hospital specialist, or APEX6 expedition doctors
•5\. Positive COVID\-19 test within 14 days prior to departure
•6\. COVID\-19 symptoms within 14 days prior to departure, without negative COVID\-19 test
•7\. Pregnancy/possible pregnancy
•8\. Smoking
•The following ‘absolute research’ exclusion criteria will prevent participants taking part in all research elements on the APEX 6 expedition (including the RESET trial), but will not prevent them from joining the APEX 6 expedition:
•9\. Subjects who have been exposed to altitude above 2500m in the two months preceding the expedition.